Document Detail

Interventions used to improve control of blood pressure in patients with hypertension.
MedLine Citation:
PMID:  20238338     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Patients with high blood pressure (hypertension) in the community frequently fail to meet treatment goals - a condition labelled as "uncontrolled" hypertension. The optimal way to organize and deliver care to hypertensive patients has not been clearly identified.
OBJECTIVES: To determine the effectiveness of interventions to improve control of blood pressure in patients with hypertension. To evaluate the effectiveness of reminders on improving the follow-up of patients with hypertension.
SEARCH STRATEGY: All-language search of all articles (any year) in the Cochrane Controlled Trials Register (CCTR) and Medline; and Embase from January 1980.
SELECTION CRITERIA: Randomized controlled trials (RCTs) of patients with hypertension that evaluated the following interventions: (1) self-monitoring (2) educational interventions directed to the patient (3) educational interventions directed to the health professional (4) health professional (nurse or pharmacist) led care (5) organisational interventions that aimed to improve the delivery of care (6) appointment reminder systemsOutcomes assessed were: (1) mean systolic and diastolic blood pressure (2) control of blood pressure (3) proportion of patients followed up at clinic
DATA COLLECTION AND ANALYSIS: Two authors extracted data independently and in duplicate and assessed each study according to the criteria outlined by the Cochrane Handbook.
MAIN RESULTS: 72 RCTs met our inclusion criteria. The methodological quality of included studies varied. An organized system of regular review allied to vigorous antihypertensive drug therapy was shown to reduce systolic blood pressure (weighted mean difference (WMD) -8.0 mmHg, 95% CI: -8.8 to -7.2 mmHg) and diastolic blood pressure (WMD -4.3 mmHg, 95% CI: -4.7 to -3.9 mmHg) for three strata of entry blood pressure, and all-cause mortality at five years follow-up (6.4% versus 7.8%, difference 1.4%) in a single large RCT- the Hypertension Detection and Follow-Up study. Other interventions had variable effects. Self-monitoring was associated with moderate net reduction in systolic blood pressure (WMD -2.5 mmHg, 95% CI: -3.7 to -1.3 mmHg) and diastolic blood pressure (WMD -1.8 mmHg, 95% CI: -2.4 to -1.2 mmHg). RCTs of educational interventions directed at patients or health professionals were heterogeneous but appeared unlikely to be associated with large net reductions in blood pressure by themselves. Nurse or pharmacist led care may be a promising way forward, with the majority of RCTs being associated with improved blood pressure control and mean SBP and DBP but these interventions require further evaluation. Appointment reminder systems also require further evaluation due to heterogeneity and small trial numbers, but the majority of trials increased the proportion of individuals who attended for follow-up (odds ratio 0.41, 95% CI 0.32 to 0.51) and in two small trials also led to improved blood pressure control, odds ratio favouring intervention 0.54 (95% CI 0.41 to 0.73).
AUTHORS' CONCLUSIONS: Family practices and community-based clinics need to have an organized system of regular follow-up and review of their hypertensive patients. Antihypertensive drug therapy should be implemented by means of a vigorous stepped care approach when patients do not reach target blood pressure levels. Self-monitoring and appointment reminders may be useful adjuncts to the above strategies to improve blood pressure control but require further evaluation.
Liam G Glynn; Andrew W Murphy; Susan M Smith; Knut Schroeder; Tom Fahey
Related Documents :
10981158 - Is there a preferred antihypertensive therapy for isolated systolic hypertension and re...
16298268 - Treatment of hypertension in italian nephrology out-patient clinics: the thin study.
20059368 - Treatment of osteoarthritis in hypertensive patients.
11814138 - Improving the managed care of hypertension with angiotensin ii antagonists.
15278588 - Changes in coagulation and fibrinolytic activity associated with tracheal intubation.
1760378 - Does anxiety or cardiovascular reactivity have a causal role in hypertension?
Publication Detail:
Type:  Journal Article; Meta-Analysis; Review     Date:  2010-03-17
Journal Detail:
Title:  The Cochrane database of systematic reviews     Volume:  -     ISSN:  1469-493X     ISO Abbreviation:  Cochrane Database Syst Rev     Publication Date:  2010  
Date Detail:
Created Date:  2010-03-18     Completed Date:  2010-04-26     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  100909747     Medline TA:  Cochrane Database Syst Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  CD005182     Citation Subset:  IM    
Department of General Practice, National University of Ireland, No 1, Distillery Road,, Galway, Ireland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antihypertensive Agents / therapeutic use*
Blood Pressure* / drug effects
Blood Pressure Monitoring, Ambulatory
Education, Medical, Continuing
Hypertension / drug therapy,  therapy*
Patient Education as Topic
Randomized Controlled Trials as Topic
Self Care
Reg. No./Substance:
0/Antihypertensive Agents
Update Of:
Cochrane Database Syst Rev. 2006;(4):CD005182   [PMID:  17054244 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Anticonvulsants for alcohol withdrawal.
Next Document:  Bile acids for liver-transplanted patients.