Document Detail

Interventions for stimulus deprivation amblyopia.
MedLine Citation:
PMID:  16856079     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Stimulus deprivation amblyopia (SDA) develops due to an obstruction to the clear passage of light, preventing clear formation of an image on the retina for example, cataract, ptosis (droopy eyelid). It is particularly severe and can be resistant to treatment and the visual prognosis is often poor. Stimulus deprivation amblyopia is rare and precise estimates of prevalence difficult to come by; it probably constitutes less than 3% of all cases of amblyopia. In developed countries most patients present under the age of one; in less developed parts of the world presentation is likely to be significantly later than this.The mainstay of treatment is patching of the better-seeing eye but regimes vary, treatment is difficult to execute and results are often disappointing.
OBJECTIVES: The objectives of this review were to evaluate the effectiveness of occlusion treatment for SDA, determine the optimum treatment regime and factors that may affect outcome.
SEARCH STRATEGY: We searched the Cochrane Central Register of Controlled Trials - CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) on The Cochrane Library (2006, Issue 1), MEDLINE (1996 to April 2006), EMBASE (1980 to April 2006) and LILACS (Latin American and Caribbean Literature on Health Sciences) (to November 2004). There were no date or language restrictions.
SELECTION CRITERIA: We aimed to include randomised and quasi-randomised controlled trials of subjects with unilateral SDA defined as worse than 0.2 LogMAR or equivalent. There were no restrictions with respect to age, gender, ethnicity, co-morbidities, medication use, and the number of participants.
DATA COLLECTION AND ANALYSIS: Two authors independently assessed study abstracts identified by the electronic searches.
MAIN RESULTS: No trials were identified that met the inclusion criteria.
AUTHORS' CONCLUSIONS: It is not possible to conclude how effective treatment for SDA is or which treatment regime produces the best results. There is a need for further study in this area.
S Hatt; A Antonio-Santos; C Powell; S S Vedula
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-07-19
Journal Detail:
Title:  The Cochrane database of systematic reviews     Volume:  -     ISSN:  1469-493X     ISO Abbreviation:  Cochrane Database Syst Rev     Publication Date:  2006  
Date Detail:
Created Date:  2006-07-20     Completed Date:  2006-10-16     Revised Date:  2014-03-26    
Medline Journal Info:
Nlm Unique ID:  100909747     Medline TA:  Cochrane Database Syst Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  CD005136     Citation Subset:  IM    
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MeSH Terms
Amblyopia / etiology,  therapy*
Blepharoptosis / complications
Cataract / complications
Child, Preschool
Occlusive Dressings*
Treatment Outcome
Update In:
Cochrane Database Syst Rev. 2014;2:CD005136   [PMID:  24504975 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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