| Interventions for preventing and treating hyperthyroidism in pregnancy. | |
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MedLine Citation:
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PMID: 20824882 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Women with hyperthyroidism in pregnancy have increased risks of miscarriage, stillbirth, preterm birth, and intrauterine growth restriction; and they can develop severe pre-eclampsia or placental abruption. OBJECTIVES: To assess the effects of interventions for preventing or treating hyperthyroidism in pregnant women. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (28 July 2010). SELECTION CRITERIA: We intended to include randomised controlled trials comparing antithyroid treatments in pregnant women with hyperthyroidism. DATA COLLECTION AND ANALYSIS: Two review authors would have assessed trial eligibility and risk of bias, and extracted data. MAIN RESULTS: No trials were located. AUTHORS' CONCLUSIONS: As we did not identify any eligible trials, we are unable to comment on implications for practice, although early identification of hyperthyroidism before pregnancy may allow a woman to choose radioactive iodine therapy or surgery before planning to have a child. Designing and conducting a trial of antithyroid drugs for pregnant women with hyperthyroidism presents formidable challenges. Not only is hyperthyroidism a relatively rare condition, both of the two main drugs used have potential for harm, one for the mother and the other for the child. More observational research is required about the potential harms of methimazole in early pregnancy and about the potential liver damage from propylthiouracil. |
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Authors:
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Rachel Earl; Caroline A Crowther; Philippa Middleton |
Publication Detail:
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Type: Journal Article; Review Date: 2010-09-08 |
Journal Detail:
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Title: Cochrane database of systematic reviews (Online) Volume: - ISSN: 1469-493X ISO Abbreviation: Cochrane Database Syst Rev Publication Date: 2010 |
Date Detail:
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Created Date: 2010-09-08 Completed Date: 2010-10-18 Revised Date: 2010-10-21 |
Medline Journal Info:
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Nlm Unique ID: 100909747 Medline TA: Cochrane Database Syst Rev Country: England |
Other Details:
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Languages: eng Pagination: CD008633 Citation Subset: IM |
Affiliation:
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Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, The University of Adelaide, Medical School North Building, Frome Road, Adelaide, Australia, 5005. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Humans Hyperthyroidism / prevention & control, therapy* Pregnancy Pregnancy Complications / prevention & control, therapy* Randomized Controlled Trials as Topic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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