Document Detail

Interventions during pregnancy to reduce excessive gestational weight gain: a systematic review assessing current clinical evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system.
MedLine Citation:
PMID:  20840691     Owner:  NLM     Status:  MEDLINE    
BACKGROUND:   Excessive weight gain during pregnancy is common in developed countries and increases the risk of complications during pregnancy, delivery and the postpartum period, which can affect both maternal and fetal outcome. Interventions to reduce excessive gestational weight gain have previously not been systematically evaluated using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system.
OBJECTIVES:   To determine whether published trials of interventions to reduce excessive gestational weight gain are of sufficient quality and provide sufficient data to enable evidence-based recommendations to be developed for clinical practice in antenatal care.
SEARCH STRATEGY:   A literature search was conducted in the scientific databases PubMed, Cochrane Library, Cinhal and Pedro, and the reference lists of relevant articles were reviewed. The literature search was concluded on 15 August 2009.
SELECTION CRITERIA:   All randomised controlled trials (RCTs) were considered for inclusion. As the number of published RCTs was limited, we also considered for inclusion all nonrandomised intervention studies that included a control group. Systematic reviews were examined to identify additional original studies.
DATA COLLECTION AND ANALYSIS:   Two reviewers independently assessed the quality of the methods and results of all included articles. Extracted data were classified using the GRADE system.
MAIN RESULTS:   Four intervention studies with a randomised controlled design and four intervention trials with a nonrandomised controlled design met the inclusion criteria. As a consequence of important limitations in study design, inconsistency and lack of directness, the overall quality of evidence was judged to be very low using the GRADE system.
AUTHORS' CONCLUSIONS:   The results of published intervention trials are of insufficient quality to enable evidence-based recommendations to be developed for clinical practice in antenatal care.
A K Ronnberg; K Nilsson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  117     ISSN:  1471-0528     ISO Abbreviation:  BJOG     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-15     Completed Date:  2010-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  1327-34     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynaecology, Orebro University Hospital, Orebro, Sweden.
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MeSH Terms
Body Mass Index
Controlled Clinical Trials as Topic / standards
Evidence-Based Medicine
Exercise Therapy
Obesity / diet therapy,  prevention & control*
Patient Education as Topic
Pregnancy Complications / diet therapy,  prevention & control*
Prenatal Care / methods*
Randomized Controlled Trials as Topic / standards
Research Design
Weight Gain / physiology*
Young Adult
Comment In:
BJOG. 2010 Oct;117(11):1309-12   [PMID:  20862792 ]

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