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Interventional value of total flavonoids from Rhizoma Drynariae on Cathepsin K, a potential target of osteoporosis.
MedLine Citation:
PMID:  21725884     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Osteoporosis, the sixth most common disease in the world, is bringing increasingly serious harm to people's health. Cathepsin K, which plays an important role in bone resorption, is a potential target in the treatment of osteoporosis. Total flavonoids, the active ingredients in Rhizoma Drynariae, have shown obvious, therapeutic effect on osteoporosis. In previous studies, it was presumed that the mechanism for the therapeutic effect was through inhibiting the expression of Cathepsin K. However, there are still no detailed reports on some key issues such as the specific inhibitory results of total flavonoids on Cathepsin K and the pathway of inhibition and so on. Based on previous studies on total flavonoids from Rhizoma Drynariae, the pathway for the effect of, total flavonoids inhibiting Cathepsin K and their interventional value on Cathepsin K were analyzed in this paper, so as to explore the interventional feasibility and value of total flavonoids in Rhizoma Drynariae on Cathepsin K.
Authors:
Xiao-Lin Shi; Kang Liu; Lian-Guo Wu
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Publication Detail:
Type:  Journal Article     Date:  2011-07-03
Journal Detail:
Title:  Chinese journal of integrative medicine     Volume:  17     ISSN:  1672-0415     ISO Abbreviation:  Chin J Integr Med     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101181180     Medline TA:  Chin J Integr Med     Country:  China    
Other Details:
Languages:  eng     Pagination:  556-60     Citation Subset:  IM    
Affiliation:
Department of Orthopaedics, Second Hospital Affiliated to Zhejiang University of Chinese Medicine, Hangzhou, 310005, China, xlshi-2002@163.com.
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