| Interventional 4-D C-arm CT Perfusion Imaging Using Interleaved Scanning and Partial Reconstruction Interpolation. | |
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MedLine Citation:
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PMID: 22203707 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Tissue perfusion measurement during catheterguided stroke treatment in the interventional suite is currently not possible. In this work, we present a novel approach that uses a C-arm angiography system capable of CT-like imaging (C-arm CT) for this purpose. With C-arm CT one reconstructed volume can be obtained every 46 s which makes it challenging to measure the flow of an injected contrast bolus. We have developed an interleaved scanning (IS) protocol that uses several scan sequences to increase temporal sampling. Using a dedicated 4-D reconstruction approach based on partial reconstruction interpolation (PRI) we can optimally process our data. We evaluated our combined approach (IS-PRI) with simulations and a study in 5 healthy pigs. In our simulations, the cerebral blood flow values (unit: ml/100g/min) were 60 (healthy tissue) and 20 (pathological tissue). For one scan sequence the values were estimated with standard deviations of 14.3 and 2.9, respectively. For two interleaved sequences the standard deviations decreased to 3.6 and 1.5, respectively. We used perfusion CT to validate the in vivo results. With two interleaved sequences we achieved promising correlations ranging from r=0.63 to r=0.94. The results suggest that C-arm CT tissue perfusion imaging is feasible with two interleaved scan sequences. |
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Authors:
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A Fieselmann; A Ganguly; Y Deuerling-Zheng; M Zellerhoff; C Rohkohl; J Boese; J Hornegger; R Fahrig |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-23 |
Journal Detail:
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Title: IEEE transactions on medical imaging Volume: - ISSN: 1558-0062 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8310780 Medline TA: IEEE Trans Med Imaging Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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