| Intervention of TLR4 Signal Pathway Cytokines in Severe Liver Injury with Obstructive Jaundice in Rats. | |
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MedLine Citation:
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PMID: 22562737 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Obstructive jaundice is a common surgical disease and a variety of end-stage severe liver injuries still lack effective treatments. Compared to traditional liver transplantation therapy, herbal treatment is noninvasive and has fewer side effects. Research results have shown that a modified major decoction of bupleurum can reduce the toxic reaction of obstructive jaundice, even though the mechanism is unclear. A period of chronic exercise training can significantly reduce TLR4 expression in mononuclear cells and the secretion of inflammatory cell factors. Our study administered a modified major decoction of bupleurum in combination with exercise in rats with obstructive jaundice and the results indicated that applying a major bupleurum decoction in combination with moderately intense aerobic exercise showed a beneficial effect on adjusting the expression of liver inflammatory cytokines, which thus improved immunity and finally reduced the liver injury of rats with obstructive jaundice. |
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Authors:
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L Lin; W M Cai; C J Qin; L C Miao; L T Yun; Y Hua; L Weilin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-4 |
Journal Detail:
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Title: International journal of sports medicine Volume: - ISSN: 1439-3964 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8008349 Medline TA: Int J Sports Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© Georg Thieme Verlag KG Stuttgart · New York. |
Affiliation:
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Hunan Normal University, College of Physical Education, Changsha, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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