Document Detail

Intersubject and dose-related variability after intravenous administration of erythromycin.
MedLine Citation:
PMID:  7437245     Owner:  NLM     Status:  MEDLINE    
1 It is well-known that considerable variability and unpredictability in serum concentrations results from orally administered erythromycin. 2 Disposition kinetics and their variability were studies in 24 healthy subjects after a single dose of erythromycin lactobionate and four doses were studied to evaluate dose-related variability in five other subjects. 3 Erythromycin kinetics were adequately described by a classical two compartment open model with little intersubject variability. 4 Dose-related variability occurred. Clearance was independent of dose but T1/2 beta and Vdss increased with dose. 5 Data are presented to show that non-invasive sampling of urine and saliva are of limited value in studying erythromycin pharmacokinetics.
K L Austin; L E Mather; C R Philpot; P J McDonald
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  10     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1980 Sep 
Date Detail:
Created Date:  1981-02-26     Completed Date:  1981-02-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  273-9     Citation Subset:  IM    
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MeSH Terms
Dose-Response Relationship, Drug
Erythromycin / administration & dosage,  adverse effects,  metabolism*
Injections, Intravenous
Saliva / analysis
Sex Factors
Reg. No./Substance:

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