Document Detail

Interstitial and vascular type V collagen morphologic disorganization in usual interstitial pneumonia.
MedLine Citation:
PMID:  16924125     Owner:  NLM     Status:  MEDLINE    
Recent evidence suggests that type V collagen plays a role in organizing collagen fibrils, thus maintaining fibril size and spatial organization uniform. In this study we sought to characterize the importance of type V collagen morphological disorganization and to study the relationship between type V collagen, active remodeling of the pulmonary vascular/parenchyma (fibroblastic foci), and other collagen types in usual interstitial pneumonia (UIP). We examined type V collagen and several other collagens in 24 open lung biopsies with histological pattern of UIP from patients with idiopathic pulmonary fibrosis (IPF). We used immunofluorescence, morphometry, and three-dimensional reconstruction to evaluate the amount of collagen V and its interaction with the active remodeling progression in UIP, as well as types I and III collagen fibers. Active remodeling progression was significantly related to type V collagen density (p<0.05), showing a gradual and direct increase to minimal, moderate, and severe fibrosis degree in UIP and in the three different areas: normal, intervening, and mural-organizing fibrosis in UIP. Parenchymal changes were characterized by morphological disorganization of fibrillar collagen with diverse disarray and thickness when observed by three-dimensional reconstruction. We concluded that in the different temporal stages of UIP, vascular/parenchyma collagen type V is increased, in disarray, and is the most important predictor of survival.
Edwin Roger Parra; Walcy R Teodoro; Ana Paula Pereira Velosa; Cristiane Carla de Oliveira; Natalino Hajime Yoshinari; Vera Luiza Capelozzi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-08-21
Journal Detail:
Title:  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society     Volume:  54     ISSN:  0022-1554     ISO Abbreviation:  J. Histochem. Cytochem.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-20     Completed Date:  2007-01-09     Revised Date:  2014-06-04    
Medline Journal Info:
Nlm Unique ID:  9815334     Medline TA:  J Histochem Cytochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1315-25     Citation Subset:  IM    
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MeSH Terms
Blood Vessels / chemistry,  pathology
Collagen Type I / analysis
Collagen Type III / analysis
Collagen Type V / analysis*
Lung / blood supply,  chemistry,  pathology*
Lung Diseases, Interstitial / pathology*
Microscopy, Confocal / methods
Middle Aged
Procollagen / analysis*
Sensitivity and Specificity
Reg. No./Substance:
0/Collagen Type I; 0/Collagen Type III; 0/Collagen Type V; 0/Procollagen

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