Document Detail

Interstitial stereotactic radiosurgery of pilocytic astrocytomas in paediatric patients.
MedLine Citation:
PMID:  17659372     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the clinical presentation, tumour response, clinical improvement and complications in 12 children and young people with a pilocytic astrocytoma, WHO I grade 1, who were treated with interstitial radiosurgery using Iodine-125 seed implants. PATIENTS AND METHODS: Retrospective analysis of 12 patients aged under 18 years (mean 8.4 years, ranging from 8 months to 17 years of age) with a pilocytic astrocytoma treated between 1993 and 2006. Iodine-125 seeds were used as temporary implants with low-dose rate (<or=10 cGy/h) and a calculated reference dose of 60 and 100 Gy to the outer ring of the tumour. RESULTS: There was no perioperative mortality. Two patients worsened transiently, but thereafter each patient improved clinically. Eleven out of 12 tumours shrank after the treatment. The mean volume of the tumours before implantation was 17.9 cm(3). and was reduced to 60% of this volume at 6 months, to 26.5% at 12 months, to 8% at 24 months, and was less than 1% at 30-36 months One patient underwent a reimplantation to treat a recurrence 3 years after the initial treatment. Ten patients were alive 2 years after the first intervention. In the longest surving patient, there was no evidence of progression after 13.4 years of follow up.
E J Herrera; J C Viano; J M Gómez; A Surur; J C Suárez
Publication Detail:
Type:  Journal Article     Date:  2007-07-24
Journal Detail:
Title:  Acta neurochirurgica     Volume:  149     ISSN:  0001-6268     ISO Abbreviation:  Acta Neurochir (Wien)     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-27     Completed Date:  2007-10-30     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0151000     Medline TA:  Acta Neurochir (Wien)     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  887-96; discussion 896     Citation Subset:  IM    
Department of Stereotactic and Functional Neurosurgery, Sanatorio Allende, Cordoba, Argentina.
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MeSH Terms
Astrocytoma / diagnosis,  surgery*
Brain Neoplasms / diagnosis,  surgery*
Child, Preschool
Iodine Radioisotopes / therapeutic use
Magnetic Resonance Imaging
Neoplasm Recurrence, Local / surgery
Retrospective Studies
Survival Analysis
Tomography, X-Ray Computed
Treatment Outcome
Reg. No./Substance:
0/Iodine Radioisotopes

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