| Interstitial stereotactic radiosurgery of pilocytic astrocytomas in paediatric patients. | |
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MedLine Citation:
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PMID: 17659372 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the clinical presentation, tumour response, clinical improvement and complications in 12 children and young people with a pilocytic astrocytoma, WHO I grade 1, who were treated with interstitial radiosurgery using Iodine-125 seed implants. PATIENTS AND METHODS: Retrospective analysis of 12 patients aged under 18 years (mean 8.4 years, ranging from 8 months to 17 years of age) with a pilocytic astrocytoma treated between 1993 and 2006. Iodine-125 seeds were used as temporary implants with low-dose rate (<or=10 cGy/h) and a calculated reference dose of 60 and 100 Gy to the outer ring of the tumour. RESULTS: There was no perioperative mortality. Two patients worsened transiently, but thereafter each patient improved clinically. Eleven out of 12 tumours shrank after the treatment. The mean volume of the tumours before implantation was 17.9 cm(3). and was reduced to 60% of this volume at 6 months, to 26.5% at 12 months, to 8% at 24 months, and was less than 1% at 30-36 months One patient underwent a reimplantation to treat a recurrence 3 years after the initial treatment. Ten patients were alive 2 years after the first intervention. In the longest surving patient, there was no evidence of progression after 13.4 years of follow up. |
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Authors:
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E J Herrera; J C Viano; J M Gómez; A Surur; J C Suárez |
Publication Detail:
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Type: Journal Article Date: 2007-07-24 |
Journal Detail:
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Title: Acta neurochirurgica Volume: 149 ISSN: 0001-6268 ISO Abbreviation: Acta Neurochir (Wien) Publication Date: 2007 |
Date Detail:
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Created Date: 2007-08-27 Completed Date: 2007-10-30 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0151000 Medline TA: Acta Neurochir (Wien) Country: Austria |
Other Details:
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Languages: eng Pagination: 887-96; discussion 896 Citation Subset: IM |
Affiliation:
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Department of Stereotactic and Functional Neurosurgery, Sanatorio Allende, Cordoba, Argentina. hmaldonado@arnet.com.ar |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Astrocytoma / diagnosis, surgery* Brain Neoplasms / diagnosis, surgery* Child Child, Preschool Female Humans Infant Iodine Radioisotopes / therapeutic use Magnetic Resonance Imaging Male Neoplasm Recurrence, Local / surgery Radiosurgery* Retreatment Retrospective Studies Survival Analysis Tomography, X-Ray Computed Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Iodine Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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