Document Detail

Interstitial pulmonary fibrosis after severe exposure to welding fumes.
MedLine Citation:
PMID:  11920969     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Interstitial pulmonary fibrosis (IPF) is reported after long term, severe exposure to welding fumes in poorly ventilated workplaces. METHODS: Fifteen welders with IPF were examined--13 in our outpatient clinic--from 1990 to 1997. Occupational histories and examinations, lung function analyses, symptoms and clinical findings, histological analyses in 13 patients partly including SEM/EDX-analyses, chest X-rays, chest computed tomographies were conducted. RESULTS: Duration of work as welders was 28 years and the cumulative dose of welding fumes 221 mg/m(3) x years (median). Lung function studies found pattern of restriction or combined restriction-obstruction, lower diffusion capacity, and reduced blood oxygen tension at exercise. Histologically, patchy interstitial fibrosis was noted. Accumulations of particulate matter typically for welding fume were detected. EDX showed increase of iron load and close topographical relationship to welding fume particles embedded in areas of scattered fibrosis. CONCLUSION: While epidemiological data are limited, it is reasonable to conclude that a causal relationship exists between IPF in welders with long term exposure to high concentrations of welding fumes.
U Buerke; J Schneider; J Rösler; H-J Woitowitz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of industrial medicine     Volume:  41     ISSN:  0271-3586     ISO Abbreviation:  Am. J. Ind. Med.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-03-28     Completed Date:  2002-05-20     Revised Date:  2006-02-27    
Medline Journal Info:
Nlm Unique ID:  8101110     Medline TA:  Am J Ind Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  259-68     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Wiley-Liss, Inc.
Institute and Outpatient Clinic for Occupational and Social Medicine, Justus-Liebig University, Giessen, Germany.
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MeSH Terms
Middle Aged
Occupational Diseases / diagnosis,  etiology*
Occupational Exposure
Pulmonary Fibrosis / diagnosis,  etiology*
Respiratory Function Tests

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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