Document Detail


Interstitial pressure, volume, and flow during infusion into brain tissue.
MedLine Citation:
PMID:  1474925     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A model of infusion-induced swelling in the brain is presented, in which gray and white matter are treated as poroelastic media. The distributions of interstitial pressure, flow, and volume are derived for steady-state and transient infusion protocols. A significant percentage increase in interstitial volume is predicted near the injection site, despite only a modest increase in tissue-averaged fluid content there. The model also can be used to estimate mechanical parameters of brain tissue, such as its hydraulic permeability, shear modulus, and Lamé constant. A solute transport equation that incorporates tissue swelling is also presented. This work suggests that knowing the distribution of swelling induced by infusion is a prerequisite to describing interstitial transport of solutes.
Authors:
P J Basser
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Microvascular research     Volume:  44     ISSN:  0026-2862     ISO Abbreviation:  Microvasc. Res.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1993-02-03     Completed Date:  1993-02-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0165035     Medline TA:  Microvasc Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  143-65     Citation Subset:  IM    
Affiliation:
Mechanical Engineering Section, National Institutes of Health, Bethesda, Maryland 20892.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport
Brain / metabolism*
Brain Diseases / physiopathology*
Extracellular Space / physiology
Humans
Infusions, Parenteral
Models, Theoretical*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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