Document Detail

Interstitial pressure, volume, and flow during infusion into brain tissue.
MedLine Citation:
PMID:  1474925     Owner:  NLM     Status:  MEDLINE    
A model of infusion-induced swelling in the brain is presented, in which gray and white matter are treated as poroelastic media. The distributions of interstitial pressure, flow, and volume are derived for steady-state and transient infusion protocols. A significant percentage increase in interstitial volume is predicted near the injection site, despite only a modest increase in tissue-averaged fluid content there. The model also can be used to estimate mechanical parameters of brain tissue, such as its hydraulic permeability, shear modulus, and Lamé constant. A solute transport equation that incorporates tissue swelling is also presented. This work suggests that knowing the distribution of swelling induced by infusion is a prerequisite to describing interstitial transport of solutes.
P J Basser
Related Documents :
20031135 - Parallel-plate fluid flow systems for bone cell stimulation.
15961265 - Comparison between the characteristics of follicular fluid and the developmental compet...
19870845 - Physiological conditions existing in connective tissue : i. tthe method of interstitial...
707295 - Effect of afterload reduction on plasma volume during acute heart failure.
2944705 - The structure and elastic properties of arterial junctions.
18344695 - The salt-avid state of congestive heart failure revisited.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Microvascular research     Volume:  44     ISSN:  0026-2862     ISO Abbreviation:  Microvasc. Res.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1993-02-03     Completed Date:  1993-02-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0165035     Medline TA:  Microvasc Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  143-65     Citation Subset:  IM    
Mechanical Engineering Section, National Institutes of Health, Bethesda, Maryland 20892.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biological Transport
Brain / metabolism*
Brain Diseases / physiopathology*
Extracellular Space / physiology
Infusions, Parenteral
Models, Theoretical*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of hydrodynamics and leukocyte-endothelium specificity on leukocyte-endothelium interactions...
Next Document:  Intravital videomicroscopy of the chorioallantoic microcirculation: a model system for studying meta...