Document Detail

Interstitial pregnancy in a woman with congenital afibrinogenemia.
MedLine Citation:
PMID:  18834350     Owner:  NLM     Status:  MEDLINE    
Without fibrinogen replacement, pregnancies in patients with congenital afibrinogenemia end in miscarriage between 6 and 8 weeks of gestation. Studies in animal models suggest that disturbance of the embryo's decidual attachment contributes to miscarriage in afibrinogenemia. Ectopic pregnancy in human congenital afibrinogenemia has not been previously documented. We present a case of right interstitial pregnancy in a woman with congenital afibrinogenemia, who had not received the recommended fibrinogen replacement for the first 6 weeks of pregnancy. The pregnancy followed a right salpingo-oophorectomy for ovarian hemorrhage. Therefore the embryo most likely entered the uterine cavity via the left tube only to move upstream into the lumen of the interstitial portion of the right tube. Our experience suggests that disturbance of the embryo's decidual attachment may have contributed to the development of an ectopic pregnancy. Therefore, fibrinogen replacement early in the first trimester is of utmost importance.
Ikue Matsushita; Soko Uchida; Akiko Yamaguchi; Yoshihiro Tanaka; Shinji Ogawa; Kiyoko Kato; Kiyomi Tsukimori; Norio Wake
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  34     ISSN:  1341-8076     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-06     Completed Date:  2008-12-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  914-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan.
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MeSH Terms
Afibrinogenemia / complications*,  congenital
Chorionic Gonadotropin / blood
Fibrinogen / administration & dosage
Pregnancy, Tubal / etiology*
Reg. No./Substance:
0/Chorionic Gonadotropin; 9001-32-5/Fibrinogen

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