Document Detail

Interstitial pneumonia possibly due to a novel anticancer drug, TS-1: first case report.
MedLine Citation:
PMID:  11463808     Owner:  NLM     Status:  MEDLINE    
A newly approved oral fluoropyrimidine, TS-1, is a dihydropyrimide dehydrogenase (DPD)-inhibiting fluoropyrimidine (DIF) drug. We describe a case of interstitial pneumonia probably caused by TS-1. A peripheral blood lymphocytes stimulating test (DLST) with TS-1 demonstrated a substantial positive reaction. So far only three cases of TS-1-induced interstitial pneumonia have been reported but the relationship between interstitial pneumonia and TS-1 was demonstrated only in this case. Considering that interstitial pneumonia has also been reported with 5-FU, it is necessary in the future to clarify which component of this drug is directly related to interstitial pneumonia.
E Kurakawa; I Kasuga; S Ishizuka; T Yoshida; A Kunisawa; K Minemura; K Utsumi; K Ohyashiki
Related Documents :
17712748 - Pasteurella multocida sepsis and meningitis in 2-month-old twin infants after household...
12745458 - Immunohistochemical characterisation of pulmonary hyaline membrane in various types of ...
2910168 - Fulminant bacterial meningitis without meningeal signs.
8893948 - Neonatal meningitis due to moraxella catarrhalis and review of the literature.
9195358 - Pseudocholinesterase hyperactivity with succinylcholine resistance: an unusual cause of...
11816818 - Occupational dust exposure and the aetiology of cryptogenic fibrosing alveolitis.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Japanese journal of clinical oncology     Volume:  31     ISSN:  0368-2811     ISO Abbreviation:  Jpn. J. Clin. Oncol.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-07-20     Completed Date:  2001-08-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0313225     Medline TA:  Jpn J Clin Oncol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  284-6     Citation Subset:  IM    
First Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenocarcinoma / drug therapy
Antimetabolites, Antineoplastic / adverse effects*
Drug Combinations
Lung Diseases, Interstitial / chemically induced*
Oxonic Acid / adverse effects*
Pyridines / adverse effects*
Stomach Neoplasms / drug therapy
Tegafur / adverse effects*
Reg. No./Substance:
0/Antimetabolites, Antineoplastic; 0/Drug Combinations; 0/Pyridines; 150863-82-4/S 1 (combination); 17902-23-7/Tegafur; 937-13-3/Oxonic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  High dose rate interstitial brachytherapy in soft tissue sarcoma: technical aspects and results.
Next Document:  A nested variant of transitional cell carcinoma of the urinary bladder: a case report.