Document Detail

Interstitial lung disease in systemic sclerosis.
MedLine Citation:
PMID:  12751995     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate high-resolution CT (HRCT) parameters of inflammation and fibrosis in systemic sclerosis (SSc), for correlation with lung function, skin scores and exercise tolerance. MATERIAL AND METHODS: 45 SSc patients (40 women, 48.5+/-13.4 years), underwent thoracic HRCT, lung function assessment, and modified Rodnan skin scores. Exercise tolerance was also graded. HRCT were scored for extent of 4 HRCT patterns of interstitial lung disease (ILD): ground glass opacification (GGO), reticular, mixed and honeycomb pattern in each lobe. Total HRCT score, inflammation index (GGO and mixed score) and fibrosis index (reticular and honeycomb scores) were correlated with lung function and clinical parameters. RESULTS: ILD was present in 39/45 (86.7%) patients. Abnormal (<80% predicted) forced vital capacity (FVC), total lung capacity (TLC) and carbon monoxide diffusion factor (DLco) were detected in 30%, 22% and 46% of patients. Total HRCT score correlated with FVC (r=-0.43, p=0.008), FEV1 (forced expiratory volume) (r=-0.37, p=0.03), TLC (r=-0.47, p=0.003), and DLCO (r=-0.43, p=0.008); inflammatory index with DLCO (r=-0.43, p=0.008) and exercise tolerance (r=-0.39, p < 0.05); and fibrosis index with FVC (r=-0.31, p=0.05) and TLC (r=-0.38, p=0.02). Higher total HRCT score, and inflammation and fibrosis indices were found in patients with abnormal lung function. CONCLUSION: Qualitative HRCT is able to evaluate inflammation and fibrosis, showing important relationships with diffusion capacity and lung volume, respectively.
G C Ooi; M Y Mok; K W T Tsang; Y Wong; P L Khong; P C W Fung; S Chan; H F Tse; R W S Wong; W K Lam; C S Lau
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta radiologica (Stockholm, Sweden : 1987)     Volume:  44     ISSN:  0284-1851     ISO Abbreviation:  Acta Radiol     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-19     Completed Date:  2003-07-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8706123     Medline TA:  Acta Radiol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  258-64     Citation Subset:  IM    
Department of Diagnostic Radiology, The University of Hong Kong, Queen Mary Hospital, SAR China.
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MeSH Terms
Exercise Tolerance
Lung Diseases, Interstitial / complications,  radiography*
Lung Volume Measurements
Middle Aged
Pulmonary Diffusing Capacity
Respiratory Function Tests
Scleroderma, Systemic / complications*,  radiography
Skin / pathology
Tomography, X-Ray Computed*

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