Document Detail


Interstitial lung disease in scleroderma. Immune complexes in sera and bronchoalveolar lavage fluid.
MedLine Citation:
PMID:  3707630     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interstitial lung disease is a common feature of scleroderma (systemic sclerosis), and it may be a major determinant of morbidity and mortality. Analysis of bronchoalveolar lavage fluid from patients with scleroderma has shown evidence of inflammation in the lower respiratory tract of many patients. We have analyzed sera and bronchoalveolar lavage fluid from scleroderma patients for the presence of immune complexes, which may play a role in the inflammatory process. Using a solid-phase C1q enzyme-linked immunosorbent assay, we detected immune complexes in the sera of 6 of 23 patients (26%) and in none of 32 controls (P less than 0.01). All 6 patients with serum immune complexes had inflammatory cells in bronchoalveolar lavage fluid, and the presence of serum immune complexes correlated with the percentage of neutrophils in lavage fluid (P less than 0.02). Immune complexes were detected in lavage fluid of 11 of 21 patients (52%) compared with 1 of 7 normal controls (14%). Subjects having immune complexes in lavage fluid had a lower forced vital capacity than did those without lavage fluid immune complexes (P less than 0.05). The levels of immune complexes in bronchoalveolar lavage fluid exceeded those in serum by a mean of 45-fold, suggesting either local formation or selective deposition of immune complexes in the lower respiratory tract of some scleroderma patients.
Authors:
R M Silver; J F Metcalf; E C LeRoy
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  29     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-05-28     Completed Date:  1986-05-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  525-31     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigen-Antibody Complex / analysis*
Body Fluids / immunology
Bronchi
Female
Humans
Irrigation
Male
Middle Aged
Pulmonary Alveoli
Pulmonary Fibrosis / complications*,  immunology
Scleroderma, Systemic / complications*,  immunology
Grant Support
ID/Acronym/Agency:
AM-30431/AM/NIADDK NIH HHS; RR-1070/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Antigen-Antibody Complex

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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