| Interstitial lung disease in scleroderma. Immune complexes in sera and bronchoalveolar lavage fluid. | |
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MedLine Citation:
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PMID: 3707630 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interstitial lung disease is a common feature of scleroderma (systemic sclerosis), and it may be a major determinant of morbidity and mortality. Analysis of bronchoalveolar lavage fluid from patients with scleroderma has shown evidence of inflammation in the lower respiratory tract of many patients. We have analyzed sera and bronchoalveolar lavage fluid from scleroderma patients for the presence of immune complexes, which may play a role in the inflammatory process. Using a solid-phase C1q enzyme-linked immunosorbent assay, we detected immune complexes in the sera of 6 of 23 patients (26%) and in none of 32 controls (P less than 0.01). All 6 patients with serum immune complexes had inflammatory cells in bronchoalveolar lavage fluid, and the presence of serum immune complexes correlated with the percentage of neutrophils in lavage fluid (P less than 0.02). Immune complexes were detected in lavage fluid of 11 of 21 patients (52%) compared with 1 of 7 normal controls (14%). Subjects having immune complexes in lavage fluid had a lower forced vital capacity than did those without lavage fluid immune complexes (P less than 0.05). The levels of immune complexes in bronchoalveolar lavage fluid exceeded those in serum by a mean of 45-fold, suggesting either local formation or selective deposition of immune complexes in the lower respiratory tract of some scleroderma patients. |
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Authors:
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R M Silver; J F Metcalf; E C LeRoy |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Arthritis and rheumatism Volume: 29 ISSN: 0004-3591 ISO Abbreviation: Arthritis Rheum. Publication Date: 1986 Apr |
Date Detail:
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Created Date: 1986-05-28 Completed Date: 1986-05-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370605 Medline TA: Arthritis Rheum Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 525-31 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigen-Antibody Complex / analysis* Body Fluids / immunology Bronchi Female Humans Irrigation Male Middle Aged Pulmonary Alveoli Pulmonary Fibrosis / complications*, immunology Scleroderma, Systemic / complications*, immunology |
| Grant Support | |
ID/Acronym/Agency:
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AM-30431/AM/NIADDK NIH HHS; RR-1070/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigen-Antibody Complex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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