Document Detail


Interstitial lung disease in inflammatory myopathies: clinical phenotypes and prognosis.
MedLine Citation:
PMID:  23888366     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Interstitial lung disease (ILD) is a very important complication of the idiopathic inflammatory myositides (IIM), with a prevalence of approximately 40 %. Characteristic HRCT changes, most commonly NSIP, together with a restrictive ventilatory defect and an associated decline in DLco support the presence of ILD. The strongest risk factors are the presence of the anti-amino-acyl-tRNA synthetases (ARS) and anti-MDA-5 antibodies, but a raised index of suspicion for ILD should also apply to IIM patients of black ethnicity. Overall, the prognosis of ILD in IIM is good; between 50 and 66 % of cases have a stable disease course over a substantial period of time. The remaining proportion will show signs of worsening lung disease within 12 months of diagnosis. Whereas ARS antibodies and black ethnicity have no influence on ILD prognosis, detection of the anti-MDA-5 antibody carries a poor ILD outcome, in which hyperferritinaemia appears to be an important diagnostic and prognostic feature.
Authors:
Patrick D W Kiely; Felix Chua
Related Documents :
15876766 - Wolman disease: diagnosis by leucocyte acid lipase estimation.
2298356 - Polypoid menetrier's disease associated with acromegaly.
18830526 - Mandibular osteomyelitis and multiple skeletal complications in albers-schönberg disease.
12631916 - Rare diseases deserve attention.
15251566 - Syndrome of type ii polyglandular autoimmunity associated with hla-dr4 in a large kindr...
9465576 - Septic arthritis and calcium pyrophosphate deposition disease in the setting of chronic...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current rheumatology reports     Volume:  15     ISSN:  1534-6307     ISO Abbreviation:  Curr Rheumatol Rep     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-07-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888970     Medline TA:  Curr Rheumatol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  359     Citation Subset:  IM    
Affiliation:
Department of Rheumatology, St George's Healthcare NHS Trust, Blackshaw Road, London, SW17 0QT, UK, patrick.kiely@stgeorges.nhs.uk.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Treatment challenges in axial spondylarthritis and future directions.
Next Document:  2013 update: hopkins lupus cohort.