Document Detail

Interstitial lung disease in anti-Jo-1 patients with antisynthetase syndrome.
MedLine Citation:
PMID:  23203765     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the outcome of interstitial lung disease (ILD) in anti-Jo-1 patients with antisynthetase syndrome, determine predictive variables of ILD deterioration in these patients, and compare features of anti-Jo-1 patients with and without ILD.
METHODS: Ninety-one anti-Jo-1 patients were identified by medical records search in 4 medical centers. All of these patients had undergone pulmonary function tests (PFTs) and high-resolution computed tomography (HRCT) scans.
RESULTS: Sixty-six patients (72.5%) had ILD. Patients could be divided into 3 groups according to their presenting lung manifestations: acute onset of lung disease (n = 12), progressive onset of lung signs (n = 35), and asymptomatic patients exhibiting abnormalities consistent with ILD on PFTs and HRCT scans (n = 19). Sixteen patients had resolution of ILD; 39 and 11 patients experienced improvement and deterioration of ILD, respectively. ILD led to decreased functional status, since 29.8% of patients exhibited a marked reduction of activities due to ILD and 13.6% had respiratory insufficiency requiring oxygen therapy; 5 of 6 patients died due to ILD complications. Predictive parameters of ILD deterioration were HRCT scan pattern of usual interstitial pneumonia, respiratory muscle involvement, and age ≥55 years. Furthermore, anti-Jo-1 patients with ILD, compared with those without, more frequently exhibited mechanic's hands and lower creatine kinase levels.
CONCLUSION: Our findings confirm that ILD is a frequent complication in anti-Jo-1 patients, resulting in high morbidity. We suggest that patients with predictive factors of ILD deterioration may require more aggressive therapy. Finally, anti-Jo-1 patients with ILD, compared with those without, may exhibit a particular clinical phenotype.
I Marie; S Josse; P Y Hatron; S Dominique; E Hachulla; A Janvresse; P Cherin; L Mouthon; O Vittecoq; J-F Menard; F Jouen
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Arthritis care & research     Volume:  65     ISSN:  2151-4658     ISO Abbreviation:  Arthritis Care Res (Hoboken)     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-24     Completed Date:  2013-06-17     Revised Date:  2013-10-28    
Medline Journal Info:
Nlm Unique ID:  101518086     Medline TA:  Arthritis Care Res (Hoboken)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  800-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 by the American College of Rheumatology.
Centre Hospitalier Universitaire Rouen and INSERM U 905, University of Rouen IFRMP, Institute for Biochemical Research, Rouen, France.
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MeSH Terms
Antibodies, Antinuclear / blood*
Biological Markers / blood
Follow-Up Studies
Lung Diseases, Interstitial / blood*,  diagnosis,  epidemiology*
Middle Aged
Myositis / blood*,  diagnosis,  epidemiology*
Retrospective Studies
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/Biological Markers; 0/Jo-1 antibody
Comment In:
Arthritis Care Res (Hoboken). 2013 Sep;65(9):1548   [PMID:  23554341 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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