Document Detail

Interstitial lung disease associated with collagen vascular disorders: disease quantification using a computer-aided diagnosis tool.
MedLine Citation:
PMID:  18726597     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to evaluate a computer-aided diagnosis (CAD) tool compared to human observers in quantification of interstitial lung disease (ILD) in patients with collagen-vascular disorders. A total of 52 patients with rheumatoid arthritis (n=24), scleroderma (n=14) and systemic lupus erythematosus (n=14) underwent thin-section CT. Two independent observers assessed the extent of ILD (EoILD), reticulation (EoRet) and ground-glass opacity (EoGGO). CAD assessed EoILD twice. Pulmonary function tests were obtained. Statistical evaluation used 95% limits of agreement and linear regression analysis. CAD correlated well with diffusing capacity (DL(CO)) (R= -0.531, P<0.0001) and moderately with forced vital capacity (FVC) (R= -0.483, P=0.0008). There was close correlation between CAD and the readers (EoILD vs. CAD: R=0.716, P<0.0001; EoRet vs. CAD: R=0.69, P<0.0001). Subgroup analysis including patients with minimal EoGGO (<15%) strengthened the correlations between CAD and the readers, readers and PFT, and CAD and PFT. EoILD by readers correlated strongly with DL(CO) (R= -0.705, P<0.0001) and moderately with FVC (R= -0.559, P=0.0002). EoRet correlated closely with DL(CO) and moderately with FVC (DL(CO): R= -0.663; FVC: R = -0.436; P <or= 0.005). The CAD system is a promising tool for ILD quantification, showing close correlation with human observers and physiologic impairment.
K Marten; V Dicken; C Kneitz; M Höhmann; W Kenn; D Hahn; C Engelke
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Publication Detail:
Type:  Journal Article     Date:  2008-08-26
Journal Detail:
Title:  European radiology     Volume:  19     ISSN:  1432-1084     ISO Abbreviation:  Eur Radiol     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-20     Completed Date:  2009-08-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9114774     Medline TA:  Eur Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  324-32     Citation Subset:  IM    
Department of Radiology, University Hospital of Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany.
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MeSH Terms
Cohort Studies
Collagen Diseases / diagnosis*,  metabolism*
Image Processing, Computer-Assisted
Lung Diseases, Interstitial / diagnosis*,  metabolism*
Middle Aged
Models, Statistical
Regression Analysis
Reproducibility of Results
Retrospective Studies
Tomography, X-Ray Computed / methods
Vascular Diseases / diagnosis*,  metabolism*

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