| Interstitial lung disease associated with collagen vascular disorders: disease quantification using a computer-aided diagnosis tool. | |
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MedLine Citation:
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PMID: 18726597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to evaluate a computer-aided diagnosis (CAD) tool compared to human observers in quantification of interstitial lung disease (ILD) in patients with collagen-vascular disorders. A total of 52 patients with rheumatoid arthritis (n=24), scleroderma (n=14) and systemic lupus erythematosus (n=14) underwent thin-section CT. Two independent observers assessed the extent of ILD (EoILD), reticulation (EoRet) and ground-glass opacity (EoGGO). CAD assessed EoILD twice. Pulmonary function tests were obtained. Statistical evaluation used 95% limits of agreement and linear regression analysis. CAD correlated well with diffusing capacity (DL(CO)) (R= -0.531, P<0.0001) and moderately with forced vital capacity (FVC) (R= -0.483, P=0.0008). There was close correlation between CAD and the readers (EoILD vs. CAD: R=0.716, P<0.0001; EoRet vs. CAD: R=0.69, P<0.0001). Subgroup analysis including patients with minimal EoGGO (<15%) strengthened the correlations between CAD and the readers, readers and PFT, and CAD and PFT. EoILD by readers correlated strongly with DL(CO) (R= -0.705, P<0.0001) and moderately with FVC (R= -0.559, P=0.0002). EoRet correlated closely with DL(CO) and moderately with FVC (DL(CO): R= -0.663; FVC: R = -0.436; P <or= 0.005). The CAD system is a promising tool for ILD quantification, showing close correlation with human observers and physiologic impairment. |
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Authors:
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K Marten; V Dicken; C Kneitz; M Höhmann; W Kenn; D Hahn; C Engelke |
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Publication Detail:
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Type: Journal Article Date: 2008-08-26 |
Journal Detail:
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Title: European radiology Volume: 19 ISSN: 1432-1084 ISO Abbreviation: Eur Radiol Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-20 Completed Date: 2009-08-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114774 Medline TA: Eur Radiol Country: Germany |
Other Details:
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Languages: eng Pagination: 324-32 Citation Subset: IM |
Affiliation:
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Department of Radiology, University Hospital of Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany. kmarten@med.uni-goettingen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cohort Studies Collagen Diseases / diagnosis*, metabolism* Female Humans Image Processing, Computer-Assisted Lung Diseases, Interstitial / diagnosis*, metabolism* Male Middle Aged Models, Statistical Regression Analysis Reproducibility of Results Retrospective Studies Tomography, X-Ray Computed / methods Vascular Diseases / diagnosis*, metabolism* |
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