| Interstitial laser thermotherapy of a rat liver tumour: Effect of hepatic inflow occlusion. | |
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MedLine Citation:
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PMID: 21254140 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVE: Interstitial laser thermotherapy was used to treat rat liver tumours. The aim was to investigate the influence of temperature and temporary hepatic inflow occlusion on tumour growth and blood perfusion. STUDY DESIGN/MATERIALS AND METHODS: Liver tumours were treated at 44°C at the tumour border for 30 minutes, hepatic inflow occlusion only, or a combination of these methods. Interstitial laser Doppler flowmetry was used to measure hepatic perfusion at the tumour border during and after heat treatment, for a total time of 60 minutes. Tumour growth was evaluated 6 days after treatment. RESULTS: Tumours subjected to the combined treatment of hepatic inflow occlusion and interstitial laser thermotherapy displayed a blood perfusion reduction 30 minutes after treatment to 18 ± 5% of initial perfusion, which was significantly lower than achieved with thermotherapy alone (52 ± 10%, P = 0.02). The combined treatment and treatment with thermotherapy alone resulted in relative tumour growth of 0.3 ± 0.1 and 1.0 ± 0.2, respectively (P = 0.04). CONCLUSION: Inflow occlusion enhanced the effect of thermotherapy not by augmenting treatment temperatures but by increasing the thermal sensitivity of the tumour, reflected by an immediate effect on tumour blood perfusion. Lasers Surg. Med. 43:29-35, 2011. © 2011 Wiley-Liss, Inc. |
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Authors:
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Christian Sturesson; Kjell Ivarsson; Unne Stenram; Stefan Andersson-Engels; Karl-Göran Tranberg |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Lasers in surgery and medicine Volume: 43 ISSN: 1096-9101 ISO Abbreviation: Lasers Surg Med Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8007168 Medline TA: Lasers Surg Med Country: United States |
Other Details:
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Languages: eng Pagination: 29-35 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Department of Surgery, Clinical Sciences Lund, Lund University, SE-221 85 Lund, Sweden. christian.sturesson@skane.se. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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