| Interstitial granulomatous dermatitis: a distinct entity with characteristic histological and clinical pattern. | |
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MedLine Citation:
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PMID: 22059717 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Interstitial granulomatous dermatitis (IGD) is a rare disease for which a clinical-pathological correlation is essential to establish diagnosis. Objective and Methods: We describe the histological and clinical features of patients with IGD seen in our department from 2004 to 2010. Moreover, all cases retrieved through a literature search were critically analyzed. Results: Twelve adult patients (9 females and 3 males; mean age, 58.5 years; range 32-73) with IGD were enrolled. Lesions consisted of asymptomatic erythematous papules and plaques, symmetrically distributed on the trunk and the proximal limbs. Two patients had skin-coloured papules. Six patients had articular involvement (arthralgias, spondyloarthritis, rheumatoid arthritis) and three patients had cancer. All cases showed a predominant CD68 positive macrophage infiltrate distributed between collagen bundles of the mid- and deep dermis. Macrophages were also surrounding degenerated collagen fibers. A few neutrophils and/or eosinophils were also present. No vasculitis nor significant mucin deposition were observed. Of the 62 cases of IGD reported since 1993, 53 fulfilled stringent diagnostic criteria. Erythematous papules and plaques on the trunk and proximal limbs were the dominant manifestation. Only approximately 10% of patients had cord-like lesions. More than 50% of IGD patients had arthralgia or arthritis, and less commonly other rheumatic disorders. Disease duration is months to years, but long term prognosis seems favourable. Limitations: The importance and the nature of the association with extra-cutaneous diseases remains to be clarified. Conclusions: IGD is a distinct entity with a typical histological and clinical pattern. Patients should be screened for rheumatic and autoimmune diseases. |
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Authors:
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A Peroni; C Colato; D Schena; P Gisondi; G Girolomoni |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-7 |
Journal Detail:
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Title: The British journal of dermatology Volume: - ISSN: 1365-2133 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 British Association of Dermatologists. |
Affiliation:
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Department of Medicine, Section of Dermatology and Venereology Department of Pathology and Diagnostic, Section of Pathology, University of Verona, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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