Document Detail

Interstitial glucose profile associated with symptoms attributed to hypoglycemia by otherwise healthy women.
MedLine Citation:
PMID:  18258625     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Reports of postprandial symptoms attributed to hypoglycemia by otherwise healthy individuals appear to be relatively common in UK women. Whether these symptoms are related to blood glucose is a contentious issue, which periodic ambulatory blood glucose measurement has failed to resolve. OBJECTIVE: The authors investigated, using continuous glucose monitoring technology, whether postprandial symptoms are associated with interstitial glucose concentrations (IG) in the hypoglycemic range or with a previous fall in IG. DESIGN: Thirty healthy nonobese women (age 20-48 y) who reported symptoms attributable to hypoglycemia and 20 nonsymptomatic controls wore a subcutaneous probe in abdominal fat for 4-7 d (median: 5 d) and kept a diet and activity diary during this time. RESULTS: Twenty women reported postprandial symptoms; 41 episodes were recorded. When symptomatic, IG was < or =3.3 mmol/L in 5% of cases. A significant fall in IG over the preceding 60 min was observed before autonomic symptoms (P < 0.005). The proportion of total energy intake derived from dietary fat in the symptomatic group was higher than that in the controls (P < 0.05). The proportion of total sugars was similar between groups; however, the meal preceding symptoms had a higher percentage of energy derived from total sugars when compared with the individuals' diet over the study period (P < 0.05). CONCLUSIONS: Most symptoms attributable to hypoglycemia were not associated with an IG concentration in the hypoglycemic range. A previous fall in IG may be implicated in the etiology of autonomic symptoms, with the consumption of meals high in sugars potentially playing a role in symptom initiation.
Elizabeth J Simpson; Michelle Holdsworth; Ian A Macdonald
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  87     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-08     Completed Date:  2008-03-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  354-61     Citation Subset:  AIM; IM    
University of Nottingham, School of Biomedical Sciences, Queen's Medical Centre, Nottingham, United Kingdom.
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MeSH Terms
Blood Glucose / metabolism
Dietary Fats / administration & dosage
Dietary Sucrose / administration & dosage
Energy Intake
Glucose / metabolism*
Great Britain
Hypoglycemia / blood*
Middle Aged
Postprandial Period
Subcutaneous Fat, Abdominal / metabolism*
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Fats; 0/Dietary Sucrose; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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