Document Detail


Interstitial fluid pressure surrounding rat mesenteric venules during changes in fluid filtration.
MedLine Citation:
PMID:  11429617     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The interstitial fluid pressure (P(isf)) has been measured in the exposed superfused mesenteries of anaesthetised rats using the micropipette servo-null technique. When mesenteries were superfused with Ringer-Locke solutions, P(isf) was close to atmospheric pressure with mean +/- S.E.M. values of -0.46 +/- 0.14 cmH(2)O (n = 22). Superfusing with paraffin oil did not alter P(isf) significantly, but P(isf) could be lowered considerably by removing fluid from the upper surface of the mesentery. Measurements of P(isf) were also made in the tissues immediately outside mesenteric venules as the pressure inside these vessels and the filtration of fluid through their walls was varied. No significant changes in perivascular P(isf) could be detected even though the intravascular pressure varied from 20 to 70 cmH(2)O. Addition of histamine or the mast cell degranulating agent compound 48/80 to the superfusate had no significant effect on P(isf). The findings are relevant to experiments on the permeability of single perfused mesenteric microvessels. They strengthen the assumption, which is made in these studies, that P(isf) is close to atmospheric pressure and does not change significantly with changes in the filtration and reabsorption of fluid through the vessel walls. Experimental Physiology (2001) 86.1, 33-38.
Authors:
M Kajimura; H Wiig; R K Reed; C C Michel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental physiology     Volume:  86     ISSN:  0958-0670     ISO Abbreviation:  Exp. Physiol.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-06-28     Completed Date:  2001-08-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  33-8     Citation Subset:  IM    
Affiliation:
Cellular & Integrative Biology, Division of Biomedical Sciences, Imperial College School of Medicine, London SW7 2AZ, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Capillary Permeability / physiology*
Dehydration
Extracellular Space / physiology*
Inflammation Mediators / pharmacology
Pressure
Rats
Rats, Sprague-Dawley
Splanchnic Circulation / physiology*
Venules / physiology
Chemical
Reg. No./Substance:
0/Inflammation Mediators

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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