Document Detail

Interstitial fluid pressure in DMBA-induced rat mammary tumours.
MedLine Citation:
PMID:  6813944     Owner:  NLM     Status:  MEDLINE    
Interstitial fluid pressure (IFP) in DMBA-induced rat mammary tumours was measured by micropuncture with sharpened glass capillaries (diameter 1-3 micron) and by the 'wick-in-needle' technique (WIN). IFP in the superficial layers of the tumours (depth less than 800 micron) was measured with micropuncture, while WIN was used for measurements in deeper areas. IFP in the superficial layers of the tumours was 2.4 mmHg (SD 2.4, n=19), while IFP in deeper layers increased with increasing tumour weight. Thus central IFP in tumours weighing more than 5.5 g was 16.0 mmHg (SD 4.8, n=10), with a maximum value of 23.3 mmHg. When related to tumour histopathology a significant correlation was found between high cellular differentiation (i.e. low degree of malignancy) and high interstitial fluid pressure only. The high IFP may be secondary to a high capillary protein premeability and/or a relatively insufficient lymphatic drainage. A further rise in IFP might result from ischaemic cell swelling and/or a continuous cell proliferation within a tissue of rather low compliance. Together or alone one or more of these factors could facilitate the development of a compartment syndrome with concomitant cell death and tissue necrosis.
H Wiig; E Tveit; R Hultborn; R K Reed; L Weiss
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  42     ISSN:  0036-5513     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  1982 Apr 
Date Detail:
Created Date:  1982-12-16     Completed Date:  1982-12-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  159-64     Citation Subset:  IM    
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MeSH Terms
Extracellular Space / physiology*
Mammary Neoplasms, Experimental / chemically induced,  pathology,  physiopathology*
Rats, Inbred Strains
Reg. No./Substance:

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