Document Detail


Interstitial fluid pressure as a prognostic factor in cervical cancer following radiation therapy.
MedLine Citation:
PMID:  19773374     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To investigate tumor interstitial fluid pressure as a prognostic factor for recurrence-free survival in patients with cervical cancer following radiation therapy. EXPERIMENTAL DESIGN: Tumor interstitial fluid pressure was measured in 55 cervical cancer patients who received radiation therapy between August 1998 and September 2002. Interstitial fluid pressure measurements were made before radiation therapy (pre-radiation therapy interstitial fluid pressure) and after a median of 28.8 Gy in 16 fractions (range, 25.2-30.6 Gy in 14-17 fractions) of radiation therapy (mid-radiation therapy interstitial fluid pressure), using a modified wick-in-needle technique. Median follow-up was 74 months (range, 2-118 months). The Kaplan-Meier method with the log-rank test and Cox's proportional hazard model were used in univariate and multivariate analyses, respectively, of prognostic factors for recurrence-free survival. RESULTS: Median pre-radiation therapy and mid-radiation therapy interstitial fluid pressure were 29.0 mm Hg (range, 4.0-93.9 mm Hg) and 20.0 mm Hg (range, -1.2 to 29.6 mm Hg), respectively (P = 0.001). Pre-radiation therapy interstitial fluid pressure was significantly higher in adenocarcinomas than squamous cell carcinomas (P = 0.028). Significant reduction of interstitial fluid pressure was noted only in patients with complete responses (P = 0.002), and mid-radiation therapy interstitial fluid pressure was significantly lower in patients with complete responses (P = 0.036). In the multivariate analysis including interstitial fluid pressures and clinical variables, pre-radiation therapy interstitial fluid pressure was an independent prognostic factor for local and distant recurrence-free survival (P = 0.001 and 0.027, respectively). CONCLUSIONS: Mid-radiation therapy interstitial fluid pressure measurement may be useful in predicting radiation therapy responses, and pre-radiation therapy interstitial fluid pressure was a significant prognostic factor for local and distant relapse-free survival in patients with cervical cancer after radiation therapy.
Authors:
Seung-Gu Yeo; Jun-Sang Kim; Moon-June Cho; Ki-Hwan Kim; Jae-Sung Kim
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2009-09-22
Journal Detail:
Title:  Clinical cancer research : an official journal of the American Association for Cancer Research     Volume:  15     ISSN:  1078-0432     ISO Abbreviation:  Clin. Cancer Res.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-02     Completed Date:  2009-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502500     Medline TA:  Clin Cancer Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6201-7     Citation Subset:  IM    
Affiliation:
Department of Radiation Oncology, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / diagnosis,  mortality,  radiotherapy
Adult
Aged
Carcinoma, Squamous Cell / diagnosis*,  mortality,  radiotherapy*
Dose Fractionation
Extracellular Fluid / physiology,  radiation effects*
Female
Follow-Up Studies
Humans
Middle Aged
Pressure*
Prognosis
Radiotherapy Dosage
Survival Analysis
Treatment Outcome
Uterine Cervical Neoplasms / diagnosis*,  mortality,  radiotherapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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