Document Detail

Interstitial cells of Cajal in patients with chagasic megacolon originating from a region of old endemicity.
MedLine Citation:
PMID:  16500095     Owner:  NLM     Status:  PubMed-not-MEDLINE    
OBJECTIVE: In the present study the distribution of interstitial cells of Cajal (ICC) was evaluated in colon biopsies from chronic chagasic patients originating from a region of old endemicity for Trypanosoma cruzi and for comparison in subjects with other colon disorders. The chagasic patients had been submitted to colectomy for the investigation of other possible mechanisms underlying the physiopathogenesis of megacolons.
DESIGN STUDY: Twenty-two colon biopsies (15 from chagasic patients and 7 from nonchagasic patients) were examined. ICC were identified by immunohistochemistry by using the anti-CD117 antibody. The number of ICC was determined in longitudinal and circular muscle layers and in the myenteric plexus, and the results were analyzed by the Kruskal-Wallis and Student t-tests.
RESULTS: A reduced number of ICC was observed in all layers and in the myenteric plexus of patients with chagasic megacolon (P<0.05).
CONCLUSIONS: We conclude that the physiopathological manifestations observed in the large bowel of chagasic patients originate from alterations that occur in the ICC, which play an important role in the control of gut motility.
R S Geraldino; A J Ferreira; M A Lima; M Cabrine-Santos; E Lages-Silva; L E Ramirez
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Publication Detail:
Type:  Journal Article     Date:  2006-02-23
Journal Detail:
Title:  Pathophysiology : the official journal of the International Society for Pathophysiology / ISP     Volume:  13     ISSN:  0928-4680     ISO Abbreviation:  Pathophysiology     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-26     Completed Date:  2011-07-14     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  9433813     Medline TA:  Pathophysiology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  71-4     Citation Subset:  -    
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