Document Detail


Interstitial cells of Cajal as targets for pharmacological intervention in gastrointestinal motor disorders.
MedLine Citation:
PMID:  9357324     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interstitial cells of Cajal (ICCs) have recently been identified as the pacemaker cells for contractile activity of the gastrointestinal tract. These cells generate the electrical 'slow-wave' activity that determines the characteristic frequency of phasic contractions of the stomach, intestine and colon. Slow waves also determine the direction and velocity of propagation of peristaltic activity, in concert with the enteric nervous system. Characterization of receptors and ion channels in the ICC membrane is under way, and manipulation of slow-wave activity markedly alters movement of contents through the gut organs. Here Jan Huizinga, Lars Thuneberg, Jean-Marie Vanderwinden and Jüri Rumessen, suggest that, as ICCs are unique to the gut, they might be ideal targets for pharmacological intervention in gastrointestinal motility disorders, which are very common and costly.
Authors:
J D Huizinga; L Thuneberg; J M Vanderwinden; J J Rumessen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Trends in pharmacological sciences     Volume:  18     ISSN:  0165-6147     ISO Abbreviation:  Trends Pharmacol. Sci.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-12-04     Completed Date:  1997-12-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7906158     Medline TA:  Trends Pharmacol Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  393-403     Citation Subset:  IM    
Affiliation:
Department of Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Clocks / drug effects,  physiology*
Digestive System / cytology*,  drug effects
Digestive System Physiological Phenomena*
Gastrointestinal Agents / pharmacology*,  therapeutic use
Gastrointestinal Diseases / drug therapy*,  physiopathology*
Gastrointestinal Motility / drug effects*,  physiology*
Humans
Chemical
Reg. No./Substance:
0/Gastrointestinal Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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