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Interstitial cells of Cajal (ICC)-like-c-Kit positive cells are involved in gastritis and carcinogenesis in human stomach.
MedLine Citation:
PMID:  21573494     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
This study was executed to prove the existence of c-Kit-positive interstitial cells of Cajal (ICC)-like cells [c-Kit (+) ICC-like cells] and their possible role associated with gastric inflammation and/or carcinogenesis in human gastric mucosa. c-Kit (+) ICC-like cells were observed throughout all the layers of the gastric fundus along the greater curvature. Dense fusiform cell bodies with many processes were found in each layer. We also studied the c-Kit-positive immunoreactivity distribution pattern in the mucosa. c-Kit (+) cells were found mainly around the epithelial repair zone of the normal gastric fundus/corpus and of the fundus/corpus with non-metaplastic chronic gastritis. Notably, they were found attached to the epithelia of the repair zone in non-metaplastic chronic gastritis. In chronic gastritis with intestinal metaplasia, they were found scattered everywhere in the stroma of the gastric mucosa and did not attach to the metaplastic epithelium. We found c-Kit (+) ICC-like cells in human mucosa. They were present mainly in the stroma around the repair zone of the glands in chronic gastritis as well as in normal mucosa, whereas they seemed to redistribute over the whole mucosa in gastritis with intestinal metaplasia. These cells around the repair zone were found to be tightly attached to epithelial cells, but not to metaplastic epithelial cells. Thus, c-Kit (+) ICC-like cells appear to have a role in the epithelial recovery process and may be associated with carcinogenesis of human gastric mucosa.
Authors:
Rohyun Sung; Young Chul Kim; Hyo-Yung Yun; Woong Choi; Hun Sik Kim; Heon Kim; Kwang Ju Lee; Ra Young You; Seon Mee Park; Sei Jin Youn; Mi-Jung Kim; Won Seop Kim; Young-Jin Song; Seok-Yong Kim; Wen-Xie Xu; Sang Jin Lee
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Publication Detail:
Type:  Journal Article     Date:  2011-04-29
Journal Detail:
Title:  Oncology reports     Volume:  26     ISSN:  1791-2431     ISO Abbreviation:  Oncol. Rep.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-05-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  33-42     Citation Subset:  IM    
Affiliation:
Department of Pathology, Chungbuk National University, College of Medicine, Heungduk-gu, Cheongju, Republic of Korea.
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