Document Detail


Interstitial lung disease associated with azacitidine use: a case report.
MedLine Citation:
PMID:  20634671     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Azacitidine is a pyrimidine nucleoside analog licensed for treatment of adult patients with myelodysplastic syndrome. Azacitidine acts as an inducer of cell differentiation by causing demethylation and re-expression of genes silenced by hypermethylation. We report a 56-year-old man with myelodysplastic syndrome who developed interstitial lung disease after azacitidine therapy. Open lung biopsy revealed a nonresolving organizing pneumonia pattern and bronchocentric granulomatous pattern suggestive of drug-induced lung injury. Treatment with steroids and discontinuation of azacitidine led to resolution of interstitial lung disease. The Naranjo adverse drug reaction probability scale score indicated that the association between azacitidine and interstitial lung disease was probable. Interstitial lung disease is a serious but uncommon side effect of this relatively safe drug. The mechanism underlying this is still unclear. The patient was subsequently treated with decitabine with no recurrence of interstitial lung disease.
Authors:
Arunabh Sekhri; Chandrasekar Palaniswamy; Kusuma Kurmayagari; Ankur Kalra; Dhana R Selvaraj
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of therapeutics     Volume:  19     ISSN:  1536-3686     ISO Abbreviation:  Am J Ther     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9441347     Medline TA:  Am J Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e98-e100     Citation Subset:  IM    
Affiliation:
1Department of Medicine, New York Medical College, Valhalla, NY 2Department of Medicine, Cooper University Hospital, UMDNJ-Robert Wood Johnson Medical School, Camden, NJ.
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