Document Detail


Interstitial lung abnormalities and reduced exercise capacity.
MedLine Citation:
PMID:  22268134     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE: The relationship between interstitial lung abnormalities (ILA) and exercise capacity has not been comprehensively evaluated.
OBJECTIVES: To assess the validity of the 6-minute walk test in subjects with ILA, and to examine the association between ILA and 6-minute walk distance (6MWD).
METHODS: Spearman correlation coefficients were used to assess the strength of the relationships between 6MWD and relevant measures of dyspnea, health-related quality of life, and pulmonary function in a cohort of 2,416 people who smoke from the COPDGene study. Unadjusted and adjusted linear and logistic regression models were used to assess the strength of the association between ILA and 6MWD.
MEASUREMENTS AND MAIN RESULTS: In all subjects, and in those with ILA, 6MWD in COPDGene was associated with relevant clinical and physiologic measures. The mean 6MWD in COPDGene subjects with ILA was 386 m (SD, 128 m), and 82% and 19% of subjects with ILA had 6MWDs less than or equal to 500 and 250 m, respectively. ILA was associated with a reduced 6MWD in univariate (-30 m; 95% confidence interval, -50 to -10; P = 0.004) and multivariate models (-19 m; 95% confidence interval, -33 to -5; P = 0.008). Compared with subjects without ILA, subjects with ILA had an 80% and 77% increase in their odds to have a walk distance limited to less than or equal to 500 and 250 m, respectively. Although these findings were dependent on ILA subtype, they were not limited to those with COPD.
CONCLUSIONS: Our study demonstrates that ILA is associated with measurable decrements in the 6MWD of people who smoke. Clinical trial registered with www.clinicaltrials.gov (NCT 00608764).
Authors:
Tracy J Doyle; George R Washko; Isis E Fernandez; Mizuki Nishino; Yuka Okajima; Tsuneo Yamashiro; Miguel J Divo; Bartolome R Celli; Frank C Sciurba; Edwin K Silverman; Hiroto Hatabu; Ivan O Rosas; Gary M Hunninghake;
Related Documents :
19370044 - Physiological responses and energy cost during a simulation of a muay thai boxing match.
22050134 - Muscle damage slows oxygen uptake kinetics during moderate-intensity exercise performed...
22080314 - Creatine supplementation decreases oxidative dna damage and lipid peroxidation induced ...
22175004 - The feasibility of reducing and measuring sedentary time among overweight, non-exercisi...
758384 - Thermoregulatory sweating in palmar hyperhidrosis before and after upper thoracic sympa...
18316444 - Technique and outcome of nares amputation (trader's technique) in immature shih tzus.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-01-20
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  185     ISSN:  1535-4970     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-02     Completed Date:  2012-05-16     Revised Date:  2013-08-06    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  756-62     Citation Subset:  AIM; IM    
Affiliation:
Pulmonary and Critical Care Division, Brigham and Women's Hospital, Boston, MA 02115, USA.
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00608764
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Exercise Test
Exercise Tolerance* / physiology
Female
Humans
Lung Diseases, Interstitial / physiopathology*
Male
Middle Aged
Pulmonary Disease, Chronic Obstructive / physiopathology
Smoking / adverse effects,  physiopathology
Walking / physiology
Grant Support
ID/Acronym/Agency:
5T32 HL007633-25/HL/NHLBI NIH HHS; K08 HL092222/HL/NHLBI NIH HHS; K08 HL092222-05/HL/NHLBI NIH HHS; K23 CA157631/CA/NCI NIH HHS; K23 HL087030/HL/NHLBI NIH HHS; K23 HL089353/HL/NHLBI NIH HHS; R01 HL111024/HL/NHLBI NIH HHS; R21CA116271-2/CA/NCI NIH HHS; U01 HL089856/HL/NHLBI NIH HHS; U01 HL089897/HL/NHLBI NIH HHS; UL1 RR024153/RR/NCRR NIH HHS; UL1 TR000005/TR/NCATS NIH HHS
Comments/Corrections
Comment In:
Am J Respir Crit Care Med. 2012 Apr 1;185(7):697-9   [PMID:  22467803 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A large subgroup of mild-to-moderate asthma is persistently noneosinophilic.
Next Document:  Extracorporeal membrane oxygenation in awake patients as bridge to lung transplantation.