Interstitial lung abnormalities and reduced exercise capacity.

Interstitial lung abnormalities and reduced exercise capacity.

MedLine Citation:	PMID: 22268134 Owner: NLM Status: MEDLINE
Abstract/OtherAbstract:	RATIONALE: The relationship between interstitial lung abnormalities (ILA) and exercise capacity has not been comprehensively evaluated. OBJECTIVES: To assess the validity of the 6-minute walk test in subjects with ILA, and to examine the association between ILA and 6-minute walk distance (6MWD). METHODS: Spearman correlation coefficients were used to assess the strength of the relationships between 6MWD and relevant measures of dyspnea, health-related quality of life, and pulmonary function in a cohort of 2,416 people who smoke from the COPDGene study. Unadjusted and adjusted linear and logistic regression models were used to assess the strength of the association between ILA and 6MWD. MEASUREMENTS AND MAIN RESULTS: In all subjects, and in those with ILA, 6MWD in COPDGene was associated with relevant clinical and physiologic measures. The mean 6MWD in COPDGene subjects with ILA was 386 m (SD, 128 m), and 82% and 19% of subjects with ILA had 6MWDs less than or equal to 500 and 250 m, respectively. ILA was associated with a reduced 6MWD in univariate (-30 m; 95% confidence interval, -50 to -10; P = 0.004) and multivariate models (-19 m; 95% confidence interval, -33 to -5; P = 0.008). Compared with subjects without ILA, subjects with ILA had an 80% and 77% increase in their odds to have a walk distance limited to less than or equal to 500 and 250 m, respectively. Although these findings were dependent on ILA subtype, they were not limited to those with COPD. CONCLUSIONS: Our study demonstrates that ILA is associated with measurable decrements in the 6MWD of people who smoke. Clinical trial registered with www.clinicaltrials.gov (NCT 00608764).

Authors:	Tracy J Doyle; George R Washko; Isis E Fernandez; Mizuki Nishino; Yuka Okajima; Tsuneo Yamashiro; Miguel J Divo; Bartolome R Celli; Frank C Sciurba; Edwin K Silverman; Hiroto Hatabu; Ivan O Rosas; Gary M Hunninghake;
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Publication Detail:	Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-01-20
Journal Detail:	Title: American journal of respiratory and critical care medicine Volume: 185 ISSN: 1535-4970 ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 2012 Apr
Date Detail:	Created Date: 2012-04-02 Completed Date: 2012-05-16 Revised Date: 2012-05-18
Medline Journal Info:	Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: United States
Other Details:	Languages: eng Pagination: 756-62 Citation Subset: AIM; IM
Affiliation:	Pulmonary and Critical Care Division, Brigham and Women's Hospital, Boston, MA 02115, USA.
Data Bank Information
Bank Name/Acc. No.:	ClinicalTrials.gov/NCT00608764
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MeSH Terms
Descriptor/Qualifier:	Aged Exercise Test Exercise Tolerance* / physiology Female Humans Lung Diseases, Interstitial / physiopathology* Male Middle Aged Pulmonary Disease, Chronic Obstructive / physiopathology Smoking / adverse effects, physiopathology Walking / physiology
Grant Support
ID/Acronym/Agency:	5T32 HL007633-25/HL/NHLBI NIH HHS; K08 HL092222/HL/NHLBI NIH HHS; K08 HL092222-05/HL/NHLBI NIH HHS; K23 CA157631/CA/NCI NIH HHS; K23 HL087030/HL/NHLBI NIH HHS; K23 HL089353/HL/NHLBI NIH HHS; R21CA116271-2/CA/NCI NIH HHS; U01 HL089856/HL/NHLBI NIH HHS; U01 HL089897/HL/NHLBI NIH HHS
Comments/Corrections
Comment In:	Am J Respir Crit Care Med. 2012 Apr 1;185(7):697-9 [PMID: 22467803 ]

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