Document Detail

Interstitial K(+) in human skeletal muscle during and after dynamic graded exercise determined by microdialysis.
MedLine Citation:
PMID:  10666141     Owner:  NLM     Status:  MEDLINE    
Interstitial K(+) concentrations were measured during one-legged knee-extensor exercise by use of microdialysis with probes inserted in the vastus lateralis muscle of the subjects. K(+) in the dialysate was measured either by flame photometry or a K(+)-sensitive electrode placed in the perfusion outlet. The correction for fractional K(+) recovery was based on the assumption of identical fractional thallium loss. The interstitial K(+) was 4. 19 +/- 0.09 mM at rest and increased to 6.17 +/- 0.19, 7.48 +/- 1.18, and 9.04 +/- 0.74 mM at 10, 30, and 50 W exercise, respectively. The individual probes demonstrated large variations in interstitial K(+), and values >10 mM were obtained. The observed interstitial K(+) was markedly higher than previously found for venous K(+) concentrations at similar work intensities. The present data support a potential role for interstitial K(+) in regulation of blood flow and development of fatigue.
C Juel; H Pilegaard; J J Nielsen; J Bangsbo
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  278     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-04-07     Completed Date:  2000-04-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R400-6     Citation Subset:  IM; S    
Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, DK-2100 Copenhagen, Denmark.
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MeSH Terms
Exercise / physiology*
Extracellular Space / metabolism*
Muscle, Skeletal / metabolism*
Potassium / metabolism*
Range of Motion, Articular
Reg. No./Substance:

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