Document Detail

Interstitial Doppler optical coherence tomography.
MedLine Citation:
PMID:  16092347     Owner:  NLM     Status:  MEDLINE    
Doppler optical coherence tomography (OCT) can image tissue structure and blood flow at micrometer-scale resolution but has limited imaging depth. We report a novel, linear-scanning, needle-based Doppler OCT system using angle-polished gradient-index or ball-lensed fibers. A prototype system with a 19-guage (diameter of approximately 0.9 mm) echogenic needle is constructed and demonstrates in vivo imaging of bidirectional blood flow in rat leg and abdominal cavity. To our knowledge, this is the first demonstration of Doppler OCT through a needle probe in interstitial applications to visualize deeply situated microcirculation.
Victor X D Yang; You X Mao; Nigel Munce; Beau Standish; Walter Kucharczyk; Norman E Marcon; Brian C Wilson; I Alex Vitkin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Optics letters     Volume:  30     ISSN:  0146-9592     ISO Abbreviation:  Opt Lett     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-08-11     Completed Date:  2005-10-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708433     Medline TA:  Opt Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1791-3     Citation Subset:  IM    
University Health Network, Toronto, Ontario, Canada.
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MeSH Terms
Blood Flow Velocity / physiology
Echocardiography, Doppler / instrumentation*,  methods
Equipment Design
Equipment Failure Analysis
Feasibility Studies
Image Enhancement / instrumentation*
Microcirculation / physiology*,  ultrasonography*
Tomography, Optical Coherence / instrumentation*,  methods
Ultrasonography, Interventional / instrumentation*,  methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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