Document Detail

Interspecific cell markers and cell lineage in birds.
MedLine Citation:
PMID:  2869526     Owner:  NLM     Status:  MEDLINE    
A cell marking technique based on the structural differences existing between the interphase nucleus in two closely related species of birds, the chick and the Japanese quail, is described. In all embryonic and adult cell types of the quail, a large mass of heterochromatin is associated with the nucleolus making quail and chick cells easy to identify at the single cell level after application of any DNA-specific staining procedure and also at the electron microscope level. This method has been largely used to construct chimeras in ovo and to study dynamic processes such as cell migrations or cell lineage segregation during ontogeny. Recently monoclonal antibodies specific for either quail or chick antigenic determinants (for example, class II MHC antigens) have been prepared, increasing the interest of the quail-chick chimera system as an experimental model.
N M Le Douarin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Philosophical transactions of the Royal Society of London. Series B, Biological sciences     Volume:  312     ISSN:  0962-8436     ISO Abbreviation:  Philos. Trans. R. Soc. Lond., B, Biol. Sci.     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-04-01     Completed Date:  1986-04-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503623     Medline TA:  Philos Trans R Soc Lond B Biol Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  153-62     Citation Subset:  IM    
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MeSH Terms
Antibodies, Monoclonal / diagnostic use
Cell Differentiation*
Cell Nucleolus / analysis,  ultrastructure
Chick Embryo / analysis,  cytology*,  physiology
Genetic Markers*
Immunoglobulin M / genetics
Mice, Inbred BALB C
Neurons / physiology
Species Specificity
Thymus Gland / cytology,  embryology,  physiology
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Genetic Markers; 0/Immunoglobulin M

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