| Interspecies scaling: predicting clearance of drugs in humans. Three different approaches. | |
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MedLine Citation:
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PMID: 8893036 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The interspecies scaling approach to predict clearance in humans from animal data was tested for a wide variety of drugs. 2. Three different methods were utilized to generate plots to scale-up the clearance values: (i) method I, clearance versus body weight (simple allometric equation); (ii) method II, product of clearance and maximum life-span potential; (iii) method III, product of clearance and brain weight versus body weight. 3. The circumstances under which the three methods can be applied to predict clearance in humans were evaluated. 4. If the exponent lies between 0.55 to 0.7 then method I predicts clearance reasonably well. 5. If the exponent lies between 0.71 to 1.0 clearance can be predicted reasonably well by method II. 6. If the exponent is > 1.0 clearance can be predicted using method III. |
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Authors:
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I Mahmood; J D Balian |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Xenobiotica; the fate of foreign compounds in biological systems Volume: 26 ISSN: 0049-8254 ISO Abbreviation: Xenobiotica Publication Date: 1996 Sep |
Date Detail:
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Created Date: 1997-02-07 Completed Date: 1997-02-07 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 1306665 Medline TA: Xenobiotica Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 887-95 Citation Subset: IM |
Affiliation:
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Division of Pharmaceutical Evaluation I. Food & Drug Administration, Rockville, MD 20852, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Mathematics Metabolic Clearance Rate Pharmacokinetics* Species Specificity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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