Document Detail

The Intersection of Theory and Application in Elucidating Pattern Formation in Developmental Biology.
MedLine Citation:
PMID:  19844610     Owner:  NLM     Status:  Publisher    
We discuss theoretical and experimental approaches to three distinct developmental systems that illustrate how theory can influence experimental work and vice-versa. The chosen systems - Drosophila melanogaster, bacterial pattern formation, and pigmentation patterns - illustrate the fundamental physical processes of signaling, growth and cell division, and cell movement involved in pattern formation and development. These systems exemplify the current state of theoretical and experimental understanding of how these processes produce the observed patterns, and illustrate how theoretical and experimental approaches can interact to lead to a better understanding of development. As John Bonner said long ago'We have arrived at the stage where models are useful to suggest experiments, and the facts of the experiments in turn lead to new and improved models that suggest new experiments. By this rocking back and forth between the reality of experimental facts and the dream world of hypotheses, we can move slowly toward a satisfactory solution of the major problems of developmental biology.'
Hans G Othmer; Kevin Painter; David Umulis; Chuan Xue
Publication Detail:
Journal Detail:
Title:  Mathematical modelling of natural phenomena     Volume:  4     ISSN:  1760-6101     ISO Abbreviation:  Math Model Nat Phenom     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-10-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101512243     Medline TA:  Math Model Nat Phenom     Country:  -    
Other Details:
Languages:  ENG     Pagination:  3-82     Citation Subset:  -    
School of Mathematics and Digital Technology Center, University of Minnesota, Minneapolis, MN 55455 USA.
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Grant Support
R01 GM029123-26//NIGMS NIH HHS

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