Document Detail

Intersalt revisited: further analyses of 24 hour sodium excretion and blood pressure within and across populations. Intersalt Cooperative Research Group.
MedLine Citation:
PMID:  8634612     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To assess further the relation in Intersalt of 24 hour urinary sodium to blood pressure of individuals and populations, and the difference in blood pressure from young adulthood into middle age. DESIGN: Standardised cross sectional study within and across populations. SETTING: 52 population samples in 32 countries. SUBJECTS: 10,074 men and women aged 20-59. MAIN OUTCOME MEASURES: Association of sodium and blood pressure from within population and cross population multiple linear regression analyses with multivariate correction for regression dilution bias. Relation of sample median daily urinary sodium excretion to difference in blood pressure with age. RESULTS: In within population analyses (n = 10,074), individual 24 hour urinary sodium excretion higher by 100 mmol (for example, 170 v 70 mmol) was associated with systolic/diastolic blood pressure higher on average by 3/0 to 6/3 mm Hg (with and without body mass in analyses). Associations were larger at ages 40-59. In cross population analyses (n = 52), sample median 24 hour sodium excretion higher by 100 mmol was associated with median systolic/diastolic pressure higher on average by 5-7/2-4 mm Hg, and estimated mean difference in systolic/diastolic pressure at age 55 compared with age 25 greater by 10-11/6 mm Hg. CONCLUSIONS: The strong, positive association of urinary sodium with systolic pressure of individuals concurs with Intersalt cross population findings and results of other studies. Higher urinary sodium is also associated with substantially greater differences in blood pressure in middle age compared with young adulthood. These results support recommendations for reduction of high salt intake in populations for prevention and control of adverse blood pressure levels.
P Elliott; J Stamler; R Nichols; A R Dyer; R Stamler; H Kesteloot; M Marmot
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  BMJ (Clinical research ed.)     Volume:  312     ISSN:  0959-8138     ISO Abbreviation:  BMJ     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-07-08     Completed Date:  1996-07-08     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  8900488     Medline TA:  BMJ     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1249-53     Citation Subset:  AIM; IM    
Department of Epidemiology and Public Health, Imperial College School of Medicine at St Mary's, London.
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MeSH Terms
Aging / physiology
Blood Pressure / drug effects,  physiology*
Body Mass Index
Circadian Rhythm
Cross-Sectional Studies
Middle Aged
Multivariate Analysis
Nutrition Policy
Population Surveillance
Regression Analysis
Sodium / urine*
Sodium, Dietary / adverse effects
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Sodium, Dietary; 7440-23-5/Sodium
Comment In:
BMJ. 1997 Aug 23;315(7106):486-7   [PMID:  9284679 ]
BMJ. 1997 Aug 23;315(7106):484; author reply 487   [PMID:  9284673 ]
BMJ. 1997 Aug 23;315(7106):485; author reply 487   [PMID:  9284675 ]
BMJ. 1996 May 18;312(7041):1240-1   [PMID:  8634603 ]
BMJ. 1996 May 18;312(7041):1239-40   [PMID:  8634602 ]
BMJ. 1996 Jun 29;312(7047):1659-61   [PMID:  8664725 ]
BMJ. 1996 May 18;312(7041):1241-2   [PMID:  8634604 ]
BMJ. 1997 Aug 23;315(7106):485; author reply 487   [PMID:  9284676 ]
Erratum In:
BMJ 1997 Aug 23;315(7106):458

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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