Document Detail

Interruption of deep brain stimulation of the globus pallidus in primary generalized dystonia.
MedLine Citation:
PMID:  19908309     Owner:  NLM     Status:  MEDLINE    
Stimulation (DBS) of the globus pallidus (GP) is effective to treat generalized dystonia. Little is known about the evolution of dystonia in case of arrest after a long period of stimulation. This study describes the course of dystonia during a 48 hours period without stimulation followed by a 24 hours period after turning ON the stimulator. 14 patients with generalized dystonia treated with bilateral GP DBS for 3 years or more were recruited. Blinded video-based analysis was performed using Burke-Fahn-Marsden scale at (1) baseline (ON stimulation), (2) up to 48 hours after the stimulator was turned OFF, and (3) 24 hours after the stimulator was turned ON. 13 patients completed the 48 hours OFF-stimulation period. The dystonia movement score progressively worsened from 24.3 +/- 13.9 at baseline to 48.9 +/- 19.8 after 48 hours (P < 0.00001). The disability score also worsened from 4.4 +/- 1.2 at baseline to 5.7 +/- 1.5 after 48 hours without stimulation (P < 0.001). When the neurostimulator was turned ON, the dystonia scores returned to baseline level after 10 hours. The interruption of GP DBS in dystonia results in a progressive worsening which is rapidly reversible once the neurostimulator is turned ON.
David Grabli; Claire Ewenczyk; Maria-Clara Coelho-Braga; Christelle Lagrange; Valerie Fraix; Philippe Cornu; Alim-Louis Benabid; Marie Vidailhet; Pierre Pollak
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  24     ISSN:  1531-8257     ISO Abbreviation:  Mov. Disord.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-28     Completed Date:  2010-03-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2363-9     Citation Subset:  IM    
Copyright Information:
(c) 2009 Movement Disorder Society.
Neurology Department and Centre de R?f?rence des Maladies Neurog?n?tiques, H?pital de la Salp?tri?re, Paris, France.
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MeSH Terms
Deep Brain Stimulation / methods*
Disability Evaluation
Double-Blind Method
Dystonia / therapy*
Globus Pallidus / physiology*
Middle Aged
Severity of Illness Index
Time Factors
Young Adult

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