Document Detail

Interruption of the blood supply of femoral head: an experimental study on the pathogenesis of Legg-Calve-Perthes Disease.
MedLine Citation:
PMID:  17598118     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The etiology of LCPD still is not clear. Thrombosis has been accused in the pathogenesis of LCPD but it is not proven until now. The aim of this study is to evaluate the results of single episode of obstruction of blood supply to the femoral heads of dogs. MATERIAL AND METHOD: Blood supply femoral heads of 45 dogs was interrupted with embolisation with gel foam. The radiologic appearances, macroscopic and microscopic specimes of the hips were evaluated and compared with the human specimens of 15 LCPD patients obtained at the time of femoral osteotomies. RESULTS: After one infarct, we demonstrated changes in femoral heads of puppies showing close resemblance to the findings of LCPD in human. CONCLUSION: Obstruction of the femoral head caused by single artificial emboli caused changes in the femoral head similar to LCPD. The cause of the obstruction is obscure, intravascular and/or extravascular pathologies need specific attention, further studies focusing especially on the coagulation system are needed.
A Mumtaz Alpaslan; M Cemalettin Aksoy; Muharrem Yazici
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Publication Detail:
Type:  Journal Article     Date:  2007-06-28
Journal Detail:
Title:  Archives of orthopaedic and trauma surgery     Volume:  127     ISSN:  0936-8051     ISO Abbreviation:  Arch Orthop Trauma Surg     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-19     Completed Date:  2008-01-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011043     Medline TA:  Arch Orthop Trauma Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  485-91     Citation Subset:  IM    
Faculty of Medicine, Department of Orthopaedics and Traumatology, Hacettepe University, Zemin kat, Ankara 06100, Turkey.
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MeSH Terms
Femur Head / blood supply*
Legg-Perthes Disease / etiology*,  pathology,  radiography

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