Document Detail

Interrelationships between the concentration and size of the largest high-density lipoprotein subfraction and apolipoprotein C-I in infants at birth and follow-up at 2-3 months of age and their parents.
MedLine Citation:
PMID:  23351580     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Lipoprotein subfractions in infants may predict the risk of cardiovascular disease factors in children.
OBJECTIVE: To examine the relationships between lipid and nonlipid factors and lipoprotein subfractions in infants at birth and follow-up (FU) and in their parents.
METHODS: Prospective study in a community-based hospital of 103 families ascertained through a pregnant mother at 36 weeks gestation or older. Of 103 infants studied at birth, 85 were sampled at FU at 2-3 months of age, along with 76 fathers. Lipids, lipoproteins, and their subclasses were determined by nuclear magnetic resonance spectroscopy. Correlations of lipid-related parameters were calculated using Spearman rank correlations.
RESULTS: Female gender in infants and use of formula only were the only nonlipid variables associated with lipoprotein subfractions. LDL parameters were significantly correlated between infants at birth and FU. The largest high-density lipoprotein subfraction, H5C, was the only lipid variable significantly associated between mothers and infants at birth. Paternal low-density lipoprotein size was significantly correlated with that of infants at FU but not at birth. In each of the four groups, markedly inverse interrelationships were found between H5C and small LDL particles. At birth and at FU, apoC-I was strongly related with H5C but not TG. Conversely, apoC-I in the parents was strongly related with TG but not H5C.
CONCLUSION: Significant relationships were found between lipoprotein subfractions within infants at birth and FU and their parents. ApoC-I and H5C levels very early in life may affect the development of dyslipidemia and obesity in childhood.
Peter O Kwiterovich; Donna G Virgil; Audrey Y Chu; Victor A Khouzami; Petar Alaupovic; James D Otvos
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-19
Journal Detail:
Title:  Journal of clinical lipidology     Volume:  7     ISSN:  1933-2874     ISO Abbreviation:  J Clin Lipidol     Publication Date:    2013 Jan-Feb
Date Detail:
Created Date:  2013-01-28     Completed Date:  2013-08-15     Revised Date:  2013-11-11    
Medline Journal Info:
Nlm Unique ID:  101300157     Medline TA:  J Clin Lipidol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  29-37     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 National Lipid Association. Published by Elsevier Inc. All rights reserved.
The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
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MeSH Terms
Apolipoprotein C-I / blood*
Blood Chemical Analysis
Body Mass Index
Cardiovascular Diseases / blood,  pathology
Follow-Up Studies
Gestational Age
Hospitals, Community
Infant, Newborn
Lipoproteins, HDL / blood*,  chemistry
Magnetic Resonance Spectroscopy
Prospective Studies
Risk Factors
Triglycerides / blood
Reg. No./Substance:
0/Apolipoprotein C-I; 0/Lipoproteins, HDL; 0/Triglycerides
Comment In:
J Clin Lipidol. 2013 Sep-Oct;7(5):531-2   [PMID:  24079293 ]
J Clin Lipidol. 2013 Sep-Oct;7(5):532   [PMID:  24079294 ]

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