| Interrelationships of bacterial vaginosis and cervical inflammation. | |
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MedLine Citation:
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PMID: 11773880 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Women with cervicitis frequently have bacterial vaginosis (BV). Prior studies have suggested that BV is involved in the pathogenesis of cervicitis. GOALS: To delineate the association of BV and cervicitis and to determine whether treatment of BV results in increased resolution of cervicitis. STUDY DESIGN: Women with clinically diagnosed cervicitis and BV received doxycycline and ofloxacin and were randomized to treatment with metronidazole gel or placebo. Resolution of BV and cervicitis was assessed. RESULTS: Metronidazole gel was associated with resolution of BV. Resolution of cervicitis was associated with use of metronidazole gel versus placebo (24/27 [88.9%] versus 15/24 [62.5%]; P = 0.03). When further stratified by resolution of BV, those whose BV resolved were more likely to have resolution of cervicitis than those with persistent BV. Although these trends persisted in multivariate analyses, they did not achieve statistical significance. CONCLUSION: Univariate analyses suggest an association between BV and cervicitis. An association between the use of metronidazole gel and resolution of cervicitis was demonstrated. Hypotheses regarding the latter include nonspecific antiinflammatory effects of metronidazole, its effect on BV flora, and its effect on a specific unrecognized pathogen. |
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Authors:
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Jane R Schwebke; Heidi L Weiss |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Sexually transmitted diseases Volume: 29 ISSN: 0148-5717 ISO Abbreviation: Sex Transm Dis Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2002-01-04 Completed Date: 2002-02-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7705941 Medline TA: Sex Transm Dis Country: United States |
Other Details:
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Languages: eng Pagination: 59-64 Citation Subset: IM |
Affiliation:
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Department of Medicine and Biostatistics Center, University of Alabama at Birmingham, USA. schwebke@uab.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Administration, Topical Adult Anti-Bacterial Agents / administration & dosage Anti-Infective Agents / therapeutic use* Doxycycline / administration & dosage Drug Therapy, Combination / therapeutic use* Female Humans Metronidazole / therapeutic use* Ofloxacin / administration & dosage Uterine Cervicitis / drug therapy*, etiology Vaginosis, Bacterial / complications, drug therapy* |
| Grant Support | |
ID/Acronym/Agency:
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U19 AI38514/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Anti-Infective Agents; 443-48-1/Metronidazole; 564-25-0/Doxycycline; 82419-36-1/Ofloxacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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