| Interrelationships among noninvasive measures of postischemic macro- and microvascular reactivity. | |
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MedLine Citation:
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PMID: 18483158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The clinical importance of vascular reactivity as an early marker of atherosclerosis has been well established, and a number of established and emerging techniques have been employed to provide measurements of peripheral vascular reactivity. However, relations between these methodologies are unclear as each technique evaluates different physiological aspects related to micro- and macrovascular reactive hyperemia. To address this question, a total of 40 apparently healthy normotensive adults, 19-68 yr old, underwent 5 min of forearm suprasystolic cuff-induced ischemia followed by postischemic measurements. Measurements of vascular reactivity included 1) flow-mediated dilatation (FMD), 2) changes in pulse wave velocity between the brachial and radial artery (DeltaPWV), 3) hyperemic shear stress, 4) reactive hyperemic flow, 5) reactive hyperemia index (RHI) assessed by fingertip arterial tonometry, 6) fingertip temperature rebound (TR), and 7) skin reactive hyperemia. FMD was significantly and positively associated with RHI (r=0.47) and TR (r=0.45) (both P<0.01) but not with reactive hyperemic flow or hyperemic shear stress. There was no correlation between two measures of macrovascular reactivity (FMD and DeltaPWV). Skin reactive hyperemia was significantly associated with RHI (r=0.55) and reactive hyperemic flow (r=0.35) (both P<0.05). There was a significant association between reactive hyperemia and RHI (r=0.30; P<0.05). In more than 75% of cases, vascular reactivity measures were not significantly associated. We concluded that associations among different measures of peripheral micro- and macrovascular reactivity were modest at best. These results suggest that different physiological mechanisms may be involved in changing different measures of vascular reactivity. |
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Authors:
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Mandeep Dhindsa; Shawn M Sommerlad; Allison E DeVan; Jill N Barnes; Jun Sugawara; Obdulia Ley; Hirofumi Tanaka |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-05-15 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 105 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-05 Completed Date: 2008-10-10 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 427-32 Citation Subset: IM |
Affiliation:
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Department of Kinesiology and Health Education, University of Texas at Austin, Austin, TX 78712, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Atherosclerosis / physiopathology Blood Vessels / physiopathology* Brachial Artery / pathology, physiopathology Capillaries / physiopathology Chronic Disease Female Fingers / blood supply Humans Hyperemia / diagnosis, physiopathology Ischemia / diagnosis*, physiopathology Male Middle Aged Plethysmography Radial Artery / pathology, physiopathology Risk Factors Skin / blood supply Skin Temperature / physiology Vasodilation / physiology |
| Grant Support | |
ID/Acronym/Agency:
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AG-20966/AG/NIA NIH HHS; DA-018431/DA/NIDA NIH HHS |
| Comments/Corrections | |
Comment In:
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J Appl Physiol. 2008 Aug;105(2):398-9
[PMID:
18556427
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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