Document Detail

Interrelationships among hypoxia-inducible factor biology and acid-base equilibrium.
MedLine Citation:
PMID:  17275583     Owner:  NLM     Status:  MEDLINE    
In this article, we try to summarize the most important novel biological information on the complex interrelationships between acid-base alterations and hypoxia-inducible factor (HIF) signaling. Extracellular and intracellular acid-base alterations affect HIF signaling in part independently of hypoxia, and involve, among others, effects on cytoprotection and apoptosis. Conversely, HIF signaling may affect systemic and local acid production rates and has been implicated in the mechanism of the acute hyperventilatory response (ie, respiratory alkalosis) in response to hypoxia as well as for hypoxia-induced pulmonary artery hypertension (PAH), although the latter data are quite preliminary and can be explained by alternative mechanisms. Thus, this review calls attention to these relationships for renal physiologists and nephrologists to stimulate focused clinical observations and specific investigative efforts as proposed in this overview.
Henry N Hulter; Reto Krapf
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in nephrology     Volume:  26     ISSN:  0270-9295     ISO Abbreviation:  Semin. Nephrol.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2007-02-05     Completed Date:  2007-04-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8110298     Medline TA:  Semin Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  454-65     Citation Subset:  IM    
Department of Medicine, University of California at San Francisco, San Francisco, CA, USA.
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MeSH Terms
Acid-Base Equilibrium / physiology*
Acidosis / etiology,  metabolism
Alkalosis, Respiratory / etiology,  metabolism
Biological Transport / physiology
Hypoxia-Inducible Factor 1 / physiology*
Reg. No./Substance:
0/Hypoxia-Inducible Factor 1

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