Document Detail

Interrelationships among gastric mucosal morphology, secretion, and motility in peptic ulcer disease.
MedLine Citation:
PMID:  3720464     Owner:  NLM     Status:  MEDLINE    
Pathophysiologic abnormalities associated with ulcer disease include gastritis (particularly of the antral mucosa), excessive duodenogastric reflux, and altered motor activity of the stomach. It is not known whether these abnormalities are interrelated and whether they occur during periods of ulcer inactivity. We have tested the hypothesis that the morphological abnormalities of the gastric mucosa in inactive ulcer disease are proportional to an alteration of the gastric luminal milieu itself due to abnormal secretory and motor function. Thus, multiple endoscopic biopsies and 24-hr physiologic measurements were performed in 12 patients with well-documented ulcers in the past (seven type I gastric ulcer patients, five duodenal ulcer patients), now clinically and endoscopically in remission. Seven healthy individuals underwent similar studies and served as controls. Histologic quantification of inflammation and metaplasia (expressed as a gastritis index) was found to be significantly different among groups (P less than 0.01). Gastric ulcer patients exhibited a higher gastritis index than controls, while duodenal ulcer patients were intermediate. A significant inverse relationship was found between gastritis index and postprandial motility index (R2 = 0.59, P less than 0.01) and a nonsignificant trend between gastritis index and fasting motility index. There was no difference among groups or detectable associations between gastritis index and intragastric pH or bile acid concentration. We conclude that gastric mucosal disease, expressed as gastritis index, persists during inactive ulcer disease. There is an association with antral hypomotility, which is more strongly manifested postprandially. It is not associated with gastric pH or bile acid concentration. Gastric mucosal inflammation and antral hypomotility predispose to ulceration rather than simply accompanying it.
S C Moore; J R Malagelada; R G Shorter; A R Zinsmeister
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  31     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1986-07-29     Completed Date:  1986-07-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  673-84     Citation Subset:  AIM; IM    
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MeSH Terms
Bile Acids and Salts / analysis
Duodenal Ulcer / complications,  pathology,  physiopathology*
Gastric Acidity Determination
Gastric Mucosa / pathology*,  secretion
Gastritis / complications,  pathology,  physiopathology
Gastrointestinal Motility*
Middle Aged
Stomach Ulcer / complications,  pathology,  physiopathology*
Grant Support
Reg. No./Substance:
0/Bile Acids and Salts

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