| Interrelationships among gastric mucosal morphology, secretion, and motility in peptic ulcer disease. | |
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MedLine Citation:
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PMID: 3720464 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pathophysiologic abnormalities associated with ulcer disease include gastritis (particularly of the antral mucosa), excessive duodenogastric reflux, and altered motor activity of the stomach. It is not known whether these abnormalities are interrelated and whether they occur during periods of ulcer inactivity. We have tested the hypothesis that the morphological abnormalities of the gastric mucosa in inactive ulcer disease are proportional to an alteration of the gastric luminal milieu itself due to abnormal secretory and motor function. Thus, multiple endoscopic biopsies and 24-hr physiologic measurements were performed in 12 patients with well-documented ulcers in the past (seven type I gastric ulcer patients, five duodenal ulcer patients), now clinically and endoscopically in remission. Seven healthy individuals underwent similar studies and served as controls. Histologic quantification of inflammation and metaplasia (expressed as a gastritis index) was found to be significantly different among groups (P less than 0.01). Gastric ulcer patients exhibited a higher gastritis index than controls, while duodenal ulcer patients were intermediate. A significant inverse relationship was found between gastritis index and postprandial motility index (R2 = 0.59, P less than 0.01) and a nonsignificant trend between gastritis index and fasting motility index. There was no difference among groups or detectable associations between gastritis index and intragastric pH or bile acid concentration. We conclude that gastric mucosal disease, expressed as gastritis index, persists during inactive ulcer disease. There is an association with antral hypomotility, which is more strongly manifested postprandially. It is not associated with gastric pH or bile acid concentration. Gastric mucosal inflammation and antral hypomotility predispose to ulceration rather than simply accompanying it. |
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Authors:
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S C Moore; J R Malagelada; R G Shorter; A R Zinsmeister |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 31 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 1986 Jul |
Date Detail:
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Created Date: 1986-07-29 Completed Date: 1986-07-29 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 673-84 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bile Acids and Salts / analysis Duodenal Ulcer / complications, pathology, physiopathology* Female Gastric Acidity Determination Gastric Mucosa / pathology*, secretion Gastritis / complications, pathology, physiopathology Gastrointestinal Motility* Humans Male Manometry Middle Aged Stomach Ulcer / complications, pathology, physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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AM 26428/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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