Document Detail


Interrelationships among airway CO2, airway pressure, and breathing frequency.
MedLine Citation:
PMID:  6800986     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The breathing frequency response to changes in airway CO2 of a vascularly isolated lobe of the canine lung has previously been shown to be primarily dependent on CO2-mediated changes in airway pressure. This study was carried out to determine what contribution changes in airway pressure make in the whole lung airway CO2-mediated breathing frequency response. Mongrel dogs were anesthetized and placed on cardiopulmonary bypass. Diaphragm electromyogram (EMG) was used to monitor respiratory center output and to trigger ventilation of the lungs. Isoproterenol administered to the lungs prevented hypocapnic airway constriction but only partially blocked the decrease in breathing frequency, suggesting that in the whole lung preparation, airway CO2 in part alters breathing frequency through a direct effect on pulmonary receptors. At constant positive end-expired pressures (1-6 Torr), 0% airway CO2 produced greater increases in expiratory time than 10% CO2. Thus airway CO2 can affect breathing frequency in the absence of CO2-related changes in airway pressure at pressures that would produce lung volumes similar to those observed at end expiration in the intact animal. An argument is presented that the receptors directly affected by CO2 are probably not located in the airways constricted by hypocapnia.
Authors:
J O Nilsestuen; R L Coon; E J Zuperku; J P Kampine
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  52     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1982 Jan 
Date Detail:
Created Date:  1982-05-12     Completed Date:  1982-05-12     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  190-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbon Dioxide / pharmacology*
Dogs
Isoproterenol / pharmacology
Lung / physiology
Positive-Pressure Respiration
Pressure
Respiration / drug effects*
Respiration, Artificial
Respiratory Physiological Phenomena*
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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