Document Detail


Interrelationship between uremic toxicity and oxidative stress.
MedLine Citation:
PMID:  16825017     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Uremic syndrome is associated with several metabolic disturbances. Oxidative stress is an important factor involved in the pathologic mechanism of these changes. The goal of this study was to understand the relationship between oxidative stress markers and two compounds included among uremic toxins. Two independent studies were performed, one with 29 peritoneal dialysis patients and the other with 43 predialysis subjects. In both groups of patients, known oxidative stress markers, malonyldialdehyde (MDA) and carbonyl groups (CG) formation were measured. Additionally, in the predialysis group, glutathione in erythrocytes (GSH) was estimated. In peritoneal dialysis patients, the concentration of advanced glycation end products (AGEs) was found to be significantly increased and correlated with both markers of oxidative stress. In predialysis patients, the increment of newly described uremic toxin purine nucleotide end products (Me2PY and Me4PY) were found and significant correlation was observed between both compounds versus MDA (positive) and GSH (negative). This relationship was visible especially in patients with more advanced renal failure. CG concentration was within the normal values and did not show any correlation with estimated toxin concentrations. In summary, results of both studies suggest that the interrelationship between uremic toxicity and oxidative stress is an important component of uremic syndrome. Nevertheless, further complex studies are needed to elucidate closer pathogenic links.
Authors:
Przemysław Rutkowski; Sylwia Malgorzewicz; Ewa Slominska; Marcin Renke; Wieslawa Lysiak-Szydlowska; Julian Swierczynski; Boleslaw Rutkowski
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation     Volume:  16     ISSN:  1532-8503     ISO Abbreviation:  J Ren Nutr     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-07     Completed Date:  2006-09-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9112938     Medline TA:  J Ren Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  190-3     Citation Subset:  IM    
Affiliation:
Department of Nephrology, Transplantology, and Internal Diseases, Medical University of Gdansk, Gdansk, Poland. prut@amg.gda.pl
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MeSH Terms
Descriptor/Qualifier:
Aged
Aldehydes / analysis
Biological Markers
Female
Glycosylation End Products, Advanced / blood
Humans
Kidney Failure, Chronic / metabolism,  therapy
Male
Malondialdehyde / analysis
Middle Aged
Oxidative Stress*
Peritoneal Dialysis
Purine Nucleotides / blood
Uremia*
Chemical
Reg. No./Substance:
0/Aldehydes; 0/Biological Markers; 0/Glycosylation End Products, Advanced; 0/Purine Nucleotides; 29343-52-0/4-hydroxy-2-nonenal; 542-78-9/Malondialdehyde

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