| Interrelationship between subpressor effects of vasopressin and other vasoactive hormones in the rat. | |
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MedLine Citation:
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PMID: 6328239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Measurements of the vasoactive hormones including norepinephrine, angiotensin II and arginine vasopressin, in patients with essential hypertension generally have revealed plasma levels which are considered to be in a subpressor range. The results of recent in vivo studies from our laboratory, however, suggest that norepinephrine, angiotensin II and vasopressin all increase blood pressure by enhancing calcium movement across plasma membranes of vascular smooth muscle. Thus, subpressor levels of these three hormones may interact to increase peripheral vascular resistance and increase blood pressure. In the present study the effect of a subpressor dose of norepinephrine, angiotensin II or vasopressin to potentiate the blood pressure response to a pressor dose of one of these vasoactive hormones was demonstrated in the conscious rat. Furthermore, the combined subpressor doses of two of these three hormones caused a significant rise in blood pressure, even though each hormone by itself did not alter blood pressure. These results therefore raise the possibility that the combined vascular effects of subpressor levels of these three vasoactive hormones might contribute to some, heretofore, unexplained, states of essential hypertension. |
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Authors:
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S Ishikawa; J P Goldberg; D M Schrier; G A Aisenbrey; R W Schrier |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Mineral and electrolyte metabolism Volume: 10 ISSN: 0378-0392 ISO Abbreviation: Miner Electrolyte Metab Publication Date: 1984 |
Date Detail:
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Created Date: 1984-07-13 Completed Date: 1984-07-13 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7802196 Medline TA: Miner Electrolyte Metab Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 184-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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pharmacology* Animals Arginine Vasopressin / pharmacology* Blood Pressure / drug effects* Calcium / metabolism Drug Interactions Ion Channels / metabolism Male Muscle, Smooth, Vascular / drug effects Norepinephrine / pharmacology* Rats Rats, Inbred Strains |
| Grant Support | |
ID/Acronym/Agency:
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AM 07135/AM/NIADDK NIH HHS; AM 19928/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Ion Channels; 11128-99-7/Angiotensin II; 113-79-1/Arginine Vasopressin; 51-41-2/Norepinephrine; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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