Document Detail


Interrelationship between subpressor effects of vasopressin and other vasoactive hormones in the rat.
MedLine Citation:
PMID:  6328239     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Measurements of the vasoactive hormones including norepinephrine, angiotensin II and arginine vasopressin, in patients with essential hypertension generally have revealed plasma levels which are considered to be in a subpressor range. The results of recent in vivo studies from our laboratory, however, suggest that norepinephrine, angiotensin II and vasopressin all increase blood pressure by enhancing calcium movement across plasma membranes of vascular smooth muscle. Thus, subpressor levels of these three hormones may interact to increase peripheral vascular resistance and increase blood pressure. In the present study the effect of a subpressor dose of norepinephrine, angiotensin II or vasopressin to potentiate the blood pressure response to a pressor dose of one of these vasoactive hormones was demonstrated in the conscious rat. Furthermore, the combined subpressor doses of two of these three hormones caused a significant rise in blood pressure, even though each hormone by itself did not alter blood pressure. These results therefore raise the possibility that the combined vascular effects of subpressor levels of these three vasoactive hormones might contribute to some, heretofore, unexplained, states of essential hypertension.
Authors:
S Ishikawa; J P Goldberg; D M Schrier; G A Aisenbrey; R W Schrier
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Mineral and electrolyte metabolism     Volume:  10     ISSN:  0378-0392     ISO Abbreviation:  Miner Electrolyte Metab     Publication Date:  1984  
Date Detail:
Created Date:  1984-07-13     Completed Date:  1984-07-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7802196     Medline TA:  Miner Electrolyte Metab     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  184-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Angiotensin II / pharmacology*
Animals
Arginine Vasopressin / pharmacology*
Blood Pressure / drug effects*
Calcium / metabolism
Drug Interactions
Ion Channels / metabolism
Male
Muscle, Smooth, Vascular / drug effects
Norepinephrine / pharmacology*
Rats
Rats, Inbred Strains
Grant Support
ID/Acronym/Agency:
AM 07135/AM/NIADDK NIH HHS; AM 19928/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Ion Channels; 11128-99-7/Angiotensin II; 113-79-1/Arginine Vasopressin; 51-41-2/Norepinephrine; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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