| Interrelationship between the functional state of the central nervous system and lipid peroxidation level in brain following craniocerebral trauma. | |
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MedLine Citation:
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PMID: 7546019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The interrelationship between the functional state of the CNS and brain metabolism was studied in animals following craniocerebral trauma. Lipid peroxidation and antioxidant activity of rabbit brain were investigated a day after craniocerebral trauma. An increase in conjugated dienes, TBA-reactive products (TBARP), and fluorescent Schiff bases (SchB), and a sharp decrease in antioxidant activity in all brain regions investigated were established. The possibility of regulation of the disturbed processes by artificial alteration of the functional state of the CNS was shown. It was found that the day after stimulation of injured brain by amphetamine (phenamin) or piracetam, the values of lipid peroxidation and antioxidant activity came to the same levels as for controls. On the contrary, the depression of the CNS by phenobarbital (luminal) was not accompanied by such positive reactions. The stimulants did not possess antioxidant activity in vitro experiments on a model system. Thus, it was shown that following craniocerebral trauma, the lipid peroxidation process can be regulated by modification of the functional state of the CNS alone without special antioxidant therapy. |
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Authors:
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M S Promyslov; M L Demchuk |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid Volume: 25 ISSN: 1044-7393 ISO Abbreviation: Mol. Chem. Neuropathol. Publication Date: 1995 May |
Date Detail:
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Created Date: 1995-10-24 Completed Date: 1995-10-24 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8910358 Medline TA: Mol Chem Neuropathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 69-80 Citation Subset: IM |
Affiliation:
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Burdenko Neurosurgical Institute, Moscow, Russia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amphetamine
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pharmacology Animals Antioxidants / metabolism Behavior, Animal / physiology Brain Chemistry / drug effects, physiology* Brain Injuries / metabolism*, physiopathology* Central Nervous System / drug effects, physiopathology* Central Nervous System Stimulants / pharmacology Chinchilla Hypnotics and Sedatives / pharmacology Lipid Peroxidation / drug effects, physiology* Male Neuroprotective Agents / pharmacology Phenobarbital / pharmacology Piracetam / pharmacology Rabbits Thiobarbituric Acid Reactive Substances / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Central Nervous System Stimulants; 0/Hypnotics and Sedatives; 0/Neuroprotective Agents; 0/Thiobarbituric Acid Reactive Substances; 300-62-9/Amphetamine; 50-06-6/Phenobarbital; 7491-74-9/Piracetam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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