| Interrelationship between coagulant activity and tissue-type plasminogen activator (t-PA) system in acute ischaemic heart disease. Possible role of the endothelium. | |
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MedLine Citation:
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PMID: 1702458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with unstable angina pectoris (UAP; n = 20) and acute myocardial infarction (AMI; n = 34) were studied in the acute phase of ischaemic heart disease. We found significantly higher levels of thrombin-antithrombin-III (TAT) complexes, lower levels of systemic tissue plasminogen activator (t-PA) activity, and higher levels of plasminogen activator inhibitor (PAI) activity in the AMI patients compared to the UAP patients. In contrast to these specific changes, general acute phase reactants such as C-reactive protein, fibrinogen and von Willebrand factor did not differ significantly between the two groups. Studies of the relationship between coagulation (TAT-complexes) and fibrinolysis data revealed a significant positive correlation between plasma antigen concentrations of TAT-complexes and t-PA (P less than 0.02), and between TAT-complexes and PAI-I (P less than 0.002). These observations indicate a common pathophysiological mechanism underlying the changes in coagulation and fibrinolysis, suggesting that coagulation activity and t-PA-related fibrinolysis are interrelated processes in vivo, and probably take place at the level of the endothelial cell. |
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Authors:
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S Munkvad; J Jespersen; J Gram; C Kluft |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of internal medicine Volume: 228 ISSN: 0954-6820 ISO Abbreviation: J. Intern. Med. Publication Date: 1990 Oct |
Date Detail:
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Created Date: 1991-02-08 Completed Date: 1991-02-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8904841 Medline TA: J Intern Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 361-6 Citation Subset: IM |
Affiliation:
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Department of Clinical Chemistry, Ribe County Hospital, Esbjerg, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute-Phase Proteins
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analysis Aged Angina, Unstable / blood* Antithrombin III / analysis Blood Coagulation / physiology* Endothelium, Vascular / physiology* Fibrinolysis / physiology Humans Myocardial Infarction / blood* Peptide Hydrolases / analysis Plasminogen Inactivators / blood Tissue Plasminogen Activator / blood* |
| Chemical | |
Reg. No./Substance:
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0/Acute-Phase Proteins; 0/Plasminogen Inactivators; 0/antithrombin III-protease complex; 9000-94-6/Antithrombin III; EC 3.4.-/Peptide Hydrolases; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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