Document Detail

Interrelationship between aortic stiffness and proteinuria in chronic kidney disease.
MedLine Citation:
PMID:  20107490     Owner:  NLM     Status:  MEDLINE    
Aortic stiffness and proteinuria are cardiovascular risk factors that are generally associated with each other. We analysed whether this is true for patients with chronic kidney disease (CKD). We hypothesized that in CKD patients of young age and predominant sole renal disease, aortic stiffness has no predictive value for proteinuria. In a cross-sectional setting, 144 patients with severe-to-mild CKD (estimated glomerular filtration rate (eGFR) 0 to <90 ml min(-1) 1.73 m(-2)) were analysed for stiffness, as measured using carotid-femoral pulse wave velocity (C-F PWV), and proteinuria, as determined using protein-creatinine ratio from morning spot urine. In stepwise linear regression analysis, C-F PWV predicted protein-creatinine ratio and vice versa. Younger patients (<50 years) with proteinuria had predominant glomerulonephritis. These were characterized by lower C-F PWV despite similar renal function when compared with younger patients without glomerulonephritis. We conclude that in CKD patients a general relationship exists between aortic stiffness and proteinuria. It is noted that this relation is lost in young CKD patients with predominant sole renal disease. In this study, C-F PWV is not predictive for proteinuria as renal disease is the leading cause of proteinuria.
C R Pan; M Roos; C Schmaderer; J Lutz; J G Wang; U Heemann; M Baumann
Publication Detail:
Type:  Journal Article     Date:  2010-01-28
Journal Detail:
Title:  Journal of human hypertension     Volume:  24     ISSN:  1476-5527     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-19     Completed Date:  2010-12-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  593-9     Citation Subset:  IM    
Department of Nephrology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
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MeSH Terms
Aortic Diseases / etiology*,  physiopathology
Creatinine / urine
Cross-Sectional Studies
Glomerular Filtration Rate
Middle Aged
Proteinuria / etiology*
Renal Insufficiency, Chronic / complications*,  physiopathology,  urine
Reg. No./Substance:

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