Document Detail

Interrelationship of CB1R and ObR pathways in regulation of metabolic, neuroendocrine and behavioral responses to food restriction and voluntary wheel running.
MedLine Citation:
PMID:  24903921     Owner:  NLM     Status:  Publisher    
We hypothesized the CB1 receptor (CB1R) and leptin receptor (ObR) operate synergistically to modulate metabolic, neuro-endocrine and behavioral responses of animals exposed to a survival challenge (food restriction and wheel running). Obese-prone (OP) JCR:LA-cp rats, lacking functional leptin receptors (ObR), and Lean-prone (LP) JCR:LA-cp rats (intact ObR) were assigned to OP-C and LP-C (Control) or CBR1 antagonized (SR141716, 10mg/kgBW in food) OP-A and LP-A groups. After 32 days, rats in all groups were exposed to 1.5-h daily meals and 22.5-h voluntary wheel running, a survival challenge that normally culminates in activity-based anorexia (ABA). Rats were removed from the ABA protocol when body weight reached 75% of entry weight (starvation criterion) or after 14 days (survival criterion). LP-A rats starved faster (6.44 ± 0.24 days) than LP-C animals (8.00 ± 0.29 days); all OP rats survived the ABA challenge. LP-A rats lost weight faster than animals in all other groups (p < 0.001). Consistent with the starvation results, LP-A rats increased the rate of wheel running more rapidly than LP-C rats (p = 0.001) with no difference in hypothalamic serotonin levels. In contrast, OP-A rats showed suppression of wheel running compared to the OP-C group, (days 6-14 of ABA challenge, p < 0.001) and decreased hypothalamic serotonin levels (p < 0.01). Thus, there is an interrelationship between CB1R and ObR pathways in regulation of energy balance and physical activity. Effective clinical measures to prevent and treat a variety of disorders will require understanding of the mechanisms underlying these effects.
Abdoulaye Diane; Donna F Vine; James C Russell; C Donald Heth; W David Pierce; Spencer D Proctor
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-5
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  -     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013, Journal of Applied Physiology.
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